Myocardial and peripheral concentrations of beta-endorphin before and following myocardial ischemia and reperfusion during coronary angioplasty.

Abstract

There is substantial evidence indicating that endogenous opioid peptides are involved in the pathophysiology of myocardial ischemia and reperfusion. We measured the myocardial and peripheral concentrations of beta-endorphin before and following myocardial ischemia and reperfusion during coronary angioplasty. The results indicate that in patients with coronary artery disease, there was an augmented myocardial concentration of beta-endorphin. Moreover, there was an increased peripheral concentration of beta-endorphin following myocardial ischemia and reperfusion. The data support the previous notion that endogenous opioid peptides are involved in the pathophysiology of ischemic heart disease.

• Authors: Michael Chich-Kuang Chang, Andrew Ying-Siu Lee, Wen-Ye Lin, Tien-Jen Chen, Miin-Yaw Shyu, Wen-Fung Chang
• Journal: Japanese heart journal (Jpn Heart J) Vol. 45 Issue 3 Pg. 365-71 (May 2004) ISSN: 0021-4868 [Print] Japan
• PMID: 15240957 (Publication Type: Journal Article)

Chemical References

• Isoenzymes
• Lactic Acid
• beta-Endorphin
• Creatine Kinase
• Creatine Kinase, MB Form

Topics

• Aged
• Aged, 80 and over
• Angioplasty, Balloon, Coronary
• Blood Pressure
• Coronary Disease (blood, physiopathology, therapy)
• Creatine Kinase (blood)
• Creatine Kinase, MB Form
• Female
• Heart Rate
• Humans
• Isoenzymes (blood)
• Lactic Acid (blood)
• Male
• Middle Aged
• Myocardial Ischemia (blood, physiopathology)
• Myocardial Reperfusion
• Myocardium (chemistry)
• Pulmonary Wedge Pressure
• Stroke Volume
• beta-Endorphin (analysis, blood)