Abstract | BACKGROUND: OBJECTIVE: METHODS: This was a prospective, double-blind, case-control clinical study. 104 patients with typical lesions of acute cutaneous leishmaniasis (ACL) were included. The duration of treatment was 6 weeks. Improvement was evaluated by clinical examination and direct smear. RESULTS: The study was completed in only 66 patients: 35 patients received MA and 31 received ZS. The cure rates were 60% for MA and 83.8% for ZS. After the second and fourth weeks, the efficacy of treatment with ZS was higher than that with MA (p < 0.01), but after 6 weeks no significant differences were observed between the two groups (p > 0.05). CONCLUSION: On the basis of this trial and despite the high number of drop-outs, we consider that the intralesional injection of ZS 2% is an alternative treatment in ACL.
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Authors | Fariba Iraji, Anahita Vali, Ali Asilian, Mohamad-Ali Shahtalebi, Ali Z Momeni |
Journal | Dermatology (Basel, Switzerland)
(Dermatology)
Vol. 209
Issue 1
Pg. 46-9
( 2004)
ISSN: 1018-8665 [Print] Switzerland |
PMID | 15237267
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright 2004 S. Karger AG, Basel |
Chemical References |
- Antiprotozoal Agents
- Organometallic Compounds
- Meglumine
- Meglumine Antimoniate
- Zinc Sulfate
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Topics |
- Acute Disease
- Adolescent
- Adult
- Aged
- Antiprotozoal Agents
(administration & dosage)
- Case-Control Studies
- Child
- Child, Preschool
- Double-Blind Method
- Female
- Humans
- Injections, Intralesional
- Injections, Subcutaneous
- Leishmaniasis, Cutaneous
(drug therapy, pathology)
- Male
- Meglumine
(administration & dosage)
- Meglumine Antimoniate
- Middle Aged
- Organometallic Compounds
(administration & dosage)
- Prospective Studies
- Treatment Outcome
- Zinc Sulfate
(administration & dosage)
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