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Duration of the effect of intravitreal triamcinolone acetonide as treatment for diffuse diabetic macular edema.

AbstractPURPOSE:
To evaluate the duration of the effect of intravitreal triamcinolone acetonide on visual acuity in patients with diffuse diabetic macular edema.
DESIGN:
Clinical interventional case series.
METHODS:
Subjects were 31 patients (38 eyes) with diffuse diabetic macular edema who received an intravitreal injection of 20- to 25-mg triamcinolone acetonide. Mean follow-up time was 13.2 +/- 6.0 months (6.03-25.2 months).
RESULTS:
Visual acuity and intraocular pressure began to increase significantly (P =.003) within the first week, reaching a plateaulike maximum at 1 to 7 months postinjection, returning to baseline values 8 to 9 months postinjection.
CONCLUSIONS:
The effect of an intravitreal injection of approximately 20- to 25-mg triamcinolone acetonide in patients with diffuse diabetic macular edema lasts approximately 7 to 8 months. This information may be helpful in determining the optimal dosage of intravitreal triamcinolone acetonide for the treatment of diffuse diabetic macular edema.
AuthorsJost B Jonas, Robert F Degenring, Bernd A Kamppeter, Ingrid Kreissig, Imren Akkoyun
JournalAmerican journal of ophthalmology (Am J Ophthalmol) Vol. 138 Issue 1 Pg. 158-60 (Jul 2004) ISSN: 0002-9394 [Print] United States
PMID15234306 (Publication Type: Journal Article)
Chemical References
  • Glucocorticoids
  • Triamcinolone Acetonide
Topics
  • Aged
  • Diabetic Retinopathy (drug therapy)
  • Fluorescein Angiography
  • Glucocorticoids (administration & dosage, therapeutic use)
  • Humans
  • Injections
  • Intraocular Pressure (drug effects)
  • Macular Edema (drug therapy)
  • Time Factors
  • Tomography, Optical Coherence
  • Triamcinolone Acetonide (administration & dosage, therapeutic use)
  • Visual Acuity (drug effects)
  • Vitreous Body

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