Lonely in Paris: when one gene copy isn't enough.

Circulating platelets are continually replenished by fragmentation of terminally differentiated megakaryocytes. Processes disrupted in inherited thrombocytopenias frequently shed light on normal thrombopoietic mechanisms. An especially rare condition called Paris-Trousseau syndrome (PTS) seems to occur by virtue of hemizygous loss of the FLI1 transcription factor gene. Provocative new data suggest that FLI1 shows monoallelic expression during a brief window in megakaryocyte differentiation, which thus explains the dominant inheritance pattern of PTS despite the presence of one normal FLI1 allele.
AuthorsRamesh A Shivdasani
JournalThe Journal of clinical investigation (J Clin Invest) Vol. 114 Issue 1 Pg. 17-9 (Jul 2004) ISSN: 0021-9738 [Print] United States
PMID15232606 (Publication Type: Comment, Journal Article, Review)
Chemical References
  • DNA-Binding Proteins
  • FLI1 protein, human
  • Proto-Oncogene Protein c-fli-1
  • Trans-Activators
  • Cell Differentiation
  • Chromosomes, Human, Pair 11 (genetics)
  • DNA-Binding Proteins (genetics)
  • Gene Deletion
  • Humans
  • Megakaryocytes (pathology, physiology)
  • Proto-Oncogene Protein c-fli-1
  • Syndrome
  • Thrombocytopenia (blood, genetics)
  • Trans-Activators (genetics)
  • Transcription, Genetic (genetics)

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