Abstract | BACKGROUND: Although non-steroidal anti-inflammatory drugs ( NSAID) and spasmolytics have been used to relieve biliary colic, the role of these drugs in the natural history of biliary colic has not been clarified. The objective of the present study is to compare the efficacy of intramuscular diclofenac with intramuscular hyoscine in the treatment of pain of acute biliary colic, and to study their role in the natural history of biliary colic and in the prevention of cholelithiasis-related complications. METHODS: Seventy-two consecutive patients with biliary colic were enrolled in this prospective, randomized, double-blind study. They received either a single 75 mg intramuscular dose of diclofenac (n = 36) or similarly administered 20 mg of hyoscine (n = 36). Pain severity was recorded on a visual analogue scale 30 min, 1 h, 2 h and 4 h after injection of the drug. Patients were then followed closely for the next 72 h for persistence or relapse of pain, or development of acute cholecystitis, or drug related complications. RESULTS: CONCLUSIONS:
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Authors | Anup Kumar, Jagpreet S Deed, Bharat Bhasin, Ashok Kumar, Shaji Thomas |
Journal | ANZ journal of surgery
(ANZ J Surg)
Vol. 74
Issue 7
Pg. 573-6
(Jul 2004)
ISSN: 1445-1433 [Print] Australia |
PMID | 15230794
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Parasympatholytics
- Diclofenac
- Butylscopolammonium Bromide
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Topics |
- Acute Disease
- Adult
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Biliary Tract Diseases
(drug therapy)
- Butylscopolammonium Bromide
(therapeutic use)
- Colic
(drug therapy)
- Diclofenac
(therapeutic use)
- Double-Blind Method
- Humans
- Middle Aged
- Parasympatholytics
(therapeutic use)
- Prospective Studies
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