Cancer chemopreventive activity of rotenoids from Derris trifoliata.

Abstract	A study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) led to the isolation and identification of one new rotenoid, 6aalpha,12aalpha-12a-hydroxyelliptone ( 3), together with five other known rotenoids. In a search for novel cancer chemopreventive agents (anti-tumor promoters), we carried out a primary screening of five of the rotenoids isolated from the plant for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. The inhibitory activity of 3 was found to be equivalent to that of beta-carotene without any cytotoxicity. Deguelin ( 4) and alpha-toxicarol ( 5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. This investigation indicated that rotenoids might be valuable anti-tumor promoters.
Authors	Chihiro Ito, Masataka Itoigawa, Naoki Kojima, Hugh T-W Tan, Junko Takayasu, Harukuni Tokuda, Hoyoku Nishino, Hiroshi Furukawa
Journal	Planta medica (Planta Med) Vol. 70 Issue 6 Pg. 585-8 (Jun 2004) ISSN: 0032-0943 [Print] Germany
PMID	15229812 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Corrected and Republished Article)
Chemical References	6aalpha,12aalpha-12a-hydroxyelliptone Antigens, Viral Antineoplastic Agents, Phytogenic Benzopyrans Epstein-Barr virus early antigen Plant Extracts beta Carotene Rotenone elliptone deguelin
Topics	Animals Antigens, Viral (drug effects, physiology) Antineoplastic Agents, Phytogenic (pharmacology, therapeutic use) Benzopyrans (chemistry, pharmacology, therapeutic use) Cell Line Fabaceae (chemistry) Female Herpesvirus 4, Human (physiology) Humans Mice Mice, Inbred ICR Papilloma (chemically induced, prevention & control) Phytotherapy Plant Extracts (chemistry, pharmacology, therapeutic use) Plant Stems (chemistry) Rotenone (analogs & derivatives, pharmacology, therapeutic use) Skin Neoplasms (chemically induced, prevention & control) Virus Activation (drug effects) beta Carotene (pharmacology, therapeutic use)

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