Abstract |
Thalassemias are a group of genetic hemolytic disorders with varying phenotypes. In this study, the frequency of alpha globin gene deletions was studied in the beta-thalassemia trait, the mildest form of the disorder. Eleven out of 33 (33%) individuals were positive for alpha(-3.7 kb) deletions. None of the subjects was positive for the Southeast Asian deletion. Such a high frequency for alpha deletions has not been reported earlier in thalassemia minor. Hematological parameters are compared, and implications of this finding for genetic counseling are discussed.
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Authors | I Panigrahi, P H Ahmed Rafeeq, V P Choudhry, R Saxena |
Journal | American journal of hematology
(Am J Hematol)
Vol. 76
Issue 3
Pg. 297-9
(Jul 2004)
ISSN: 0361-8609 [Print] United States |
PMID | 15224373
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2004 Wiley-Liss, Inc. |
Chemical References |
- Globins
- Hemoglobin A2
- Fetal Hemoglobin
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Topics |
- Adolescent
- Adult
- Female
- Fetal Hemoglobin
(analysis)
- Gene Deletion
- Gene Frequency
- Genetic Counseling
- Globins
(genetics)
- Hemoglobin A2
(analysis)
- Heterozygote
- Humans
- Male
- alpha-Thalassemia
(genetics)
- beta-Thalassemia
(genetics)
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