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[Expression of the integrin alpha 6 beta 4 and effects of integrin alpha 6 beta 4 on adhesive and invasive behaviors of human laryngeal carcinoma cell lines].

AbstractOBJECTIVE:
To study the expression of integrin alpha 6 beta 4 in human laryngeal carcinoma cell lines Hep-2 and AMC-HN8. To explore the mechanism and the effects of integrin alpha 6 beta 4 in human laryngeal carcinoma cell lines.
METHOD:
Flowcytometry was used to exame the surface expression of integrin alpha 6 beta 4 in human laryngeal carcinoma cell lines. Anti-alpha 6 and anti-beta 4 specific monoclonal antibody were used in adherence inhibition assay and in vitro invasion assay.
RESULT:
Overexpression of integrin alpha 6 beta 4 were present in both Hep-2 and AMC-HN8 cell lines. Anti-alpha 6 and anti-beta 4 specific monoclonal antibody together blocked the alpha 6 beta 4 on the surface of the cells resulting in low adherence on the extracellular matrix and weak invasion through the extracellular matrix.
CONCLUSION:
Integrin alpha 6 beta 4 play a vitral role in the adhension and invasion of laryngeal carcinoma. Anti-alpha 6 and anti-beta 4 specific monoclonal antibody together can block the function of integrin alpha 6 beta 4. So treatment with anti-alpha 6 and anti-beta 4 specific monoclonal antibody may reduce the development of laryngeal carcinoma.
AuthorsJiaqing Zhou, Liang Zhou, Xiaojie Jin
JournalLin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology (Lin Chuang Er Bi Yan Hou Ke Za Zhi) Vol. 18 Issue 3 Pg. 164-6 (Mar 2004) China
PMID15222271 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Integrin alpha6beta4
Topics
  • Antibodies, Monoclonal (pharmacology)
  • Cell Adhesion
  • Cell Line, Tumor
  • Extracellular Matrix
  • Humans
  • Integrin alpha6beta4 (biosynthesis, physiology)
  • Laryngeal Neoplasms (metabolism, pathology)
  • Neoplasm Invasiveness

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