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A case of steroid responsive pulmonary hyalinising granuloma: complicated by deep venous thrombosis.

Abstract
A case of pulmonary hyalinising granuloma (PHG) complicated by deep venous thrombosis (DVT) is presented. The DVT was associated with the presence of a lupus anticoagulant. In the past PHG has been linked to various auto-antibodies, but to the best of the authors' knowledge, this is the first case reporting PHG in association with a lupus anticoagulant and clinically significant venous thrombosis. Historically, PHG has been regarded as poorly corticosteroid responsive. However, the patient in this case study responded dramatically to prednisone. This case study suggests that in selected patients with pulmonary hyalinising granuloma experiencing disabling symptoms and worsening pulmonary function, a trial of corticosteroids may be warranted.
AuthorsK M A O'Reilly, J A Boscia, K L Kaplan, P J Sime
JournalThe European respiratory journal (Eur Respir J) Vol. 23 Issue 6 Pg. 954-6 (Jun 2004) ISSN: 0903-1936 [Print] England
PMID15219012 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anticoagulants
  • Lupus Coagulation Inhibitor
Topics
  • Anticoagulants (therapeutic use)
  • Granuloma, Respiratory Tract (complications, pathology)
  • Humans
  • Lung Diseases (complications, pathology)
  • Lupus Coagulation Inhibitor (immunology)
  • Male
  • Middle Aged
  • Venous Thrombosis (complications, drug therapy, immunology)

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