Osteosarcoma as a second tumor after treatment for primary non-Hodgkin's lymphoma in a child with ataxia-telangiectasia: presentation of a case and review of possible pathogenetic mechanisms.

Abstract

Patients with ataxia-telangiectasia (A-T) and cancer are exposed to additional toxicity due to their underlying inability to repair chemotherapy-induced DNA damage. The authors report the development of osteosarcoma as a second neoplasia in a child with A-T who was treated, without being irradiated, for non-Hodgkin's lymphoma as a primary malignancy. This is the first report of osteosarcoma associated with A-T. The authors postulate that the mechanisms of carcinogenesis are common and independent of the different histopathology categories of these two neoplasias, and the underlying "canvas" of the A-T mutated gene was further triggered by chemotherapy, leading to the development of a second malignancy.

• Authors: Alexandros Makis, Sophia Polychronopoulou, Stavros Haidas
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 26 Issue 7 Pg. 444-6 (Jul 2004) ISSN: 1077-4114 [Print] United States
• PMID: 15218420 (Publication Type: Case Reports, Journal Article)

Topics

• Ataxia Telangiectasia (complications)
• Bone Neoplasms (complications, pathology)
• Child
• Humans
• Lymphoma, Non-Hodgkin (complications, pathology)
• Male
• Neoplasms, Second Primary (complications, pathology)
• Osteosarcoma (complications, pathology)