Secondary acute promyelocytic leukemia following chemotherapy for non-Hodgkin's lymphoma in a child.

Abstract

Of the several kinds of therapy-related leukemia, therapy-related acute promyelocytic leukemia (t-APL) is most closely associated with topoisomerase II inhibitor administration for treatment of malignancies in adults. Although rare in children, the majority of therapy-related malignancies have been etoposide-related APL associated with Langerhans cell histiocytosis. The authors describe the development of t-APL after chemotherapy administered for non-Hodgkin's lymphoma (NHL) in an 8-year-old girl. One month after cessation of the 3-year chemotherapy regimen of doxorubicin and other agents but not etoposide or radiotherapy, the patient was diagnosed with t-APL with positive PML-RARA molecular abnormality. The patient attained a complete remission following treatment with all-trans retinoic acid-containing chemotherapy. Thereafter, she successfully received hematopoietic stem cell transplantation from an HLA-matched sibling donor. Development of t-APL associated with NHL in children appears to be rare.

• Authors: Aya Ogami, Akira Morimoto, Shigeyoshi Hibi, Shinjiro Todo, Tohru Sugimoto, Kanako Mori, Toshihiko Imamura, Hiroyuki Ishida, Takao Yoshihara, Akihiro Iguchi, Masue Imaizumi, Shinsaku Imashuku
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 26 Issue 7 Pg. 427-30 (Jul 2004) ISSN: 1077-4114 [Print] United States
• PMID: 15218416 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents

Topics

• Antineoplastic Agents (adverse effects)
• Bone Marrow (pathology)
• Bone Marrow Transplantation
• Child, Preschool
• Chromosomes, Human, Pair 15
• Chromosomes, Human, Pair 17
• Female
• Humans
• Leukemia, Promyelocytic, Acute (pathology)
• Lymphoma, Non-Hodgkin (drug therapy, pathology)
• Neoplasms, Second Primary (pathology, therapy)
• Polymerase Chain Reaction
• Remission Induction
• Translocation, Genetic