Abstract | OBJECTIVE: METHODS: The authors studied 32 samples of cartilage tumors from our tumor tissue bank for the presence of COX-2 by a Western blot technique. There were 29 patients from whom the samples were obtained, including 8 with enchondromas and 21 with chondrosarcomas. RESULTS: Thirteen of the 24 chondrosarcoma samples and none of the 8 enchondromas were positive for COX-2. An attempt was made to correlate these results with clinical data including age, gender, staging according to the Musculoskeletal Tumor Society, anatomical site, ploidic pattern, presence of metastases and death rate but no statistically valid correlation could be found. CONCLUSION:
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Authors | Karen M Sutton, Marianne Wright, Gertrud Fondren, Christine A Towle, Henry J Mankin |
Journal | Oncology
(Oncology)
Vol. 66
Issue 4
Pg. 275-80
( 2004)
ISSN: 0030-2414 [Print] Switzerland |
PMID | 15218294
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Copyright | Copyright 2004 S. Karger AG, Basel |
Chemical References |
- Biomarkers, Tumor
- Isoenzymes
- Membrane Proteins
- Cyclooxygenase 2
- PTGS2 protein, human
- Prostaglandin-Endoperoxide Synthases
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(analysis)
- Bone Neoplasms
(enzymology, pathology)
- Chondroma
(enzymology)
- Chondrosarcoma
(enzymology, secondary)
- Cyclooxygenase 2
- Female
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Humans
- Isoenzymes
(analysis)
- Male
- Membrane Proteins
- Middle Aged
- Ploidies
- Prostaglandin-Endoperoxide Synthases
(analysis)
|