Abstract | BACKGROUND: Nonheme- iron absorption requires an acidic milieu. Reduced gastric acid output as a consequence of Helicobacter pylori infection could be an important limiting factor for iron absorption. OBJECTIVE: DESIGN: Gastric acid output was quantified before (basal acid output, or BAO) and after pentagastrin stimulation (stimulated acid output, or SAO) in 2-5-y-old children with iron deficiency anemia who were (n = 13) or were not (n = 12) infected with H. pylori. Iron absorption was measured by using a double-stable- isotope technique. H. pylori-infected children were studied before and after eradication therapy. RESULTS: BAO and SAO were significantly lower in the H. pylori-infected children (0.2 +/- 0.2 and 1.6 +/- 0.9 mmol/h, respectively) than in the uninfected children (0.9 +/- 0.7 and 3.1 +/- 0.9 mmol/h, respectively; P = 0.01 and P < 0.005). BAO and SAO improved to 0.8 +/- 1.3 and 3.3 +/- 2.4 mmol/h, respectively, after therapy. Iron absorption from ferrous sulfate was significantly greater than that from ferrous fumarate both before (geometric : 19.7% compared with 5.3%; P < 0.0001) and after (22.5% compared with 6.4%; P < 0.0001) treatment in H. pylori-infected children. Corresponding values for uninfected children were 15.6% and 5.4%, respectively (P < 0.001; n = 12). CONCLUSIONS:
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Authors | Shafiqul A Sarker, Lena Davidsson, Hasan Mahmud, Thomas Walczyk, Richard F Hurrell, Niklaus Gyr, George J Fuchs |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 80
Issue 1
Pg. 149-53
(Jul 2004)
ISSN: 0002-9165 [Print] United States |
PMID | 15213042
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Ferrous Compounds
- ferrous sulfate
- Iron
- ferrous fumarate
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Topics |
- Anemia, Iron-Deficiency
(metabolism, prevention & control)
- Bangladesh
- Biological Availability
- Child, Preschool
- Female
- Ferrous Compounds
(pharmacokinetics)
- Food, Fortified
- Gastric Acid
(metabolism)
- Gastric Acidity Determination
- Helicobacter Infections
(drug therapy, physiopathology)
- Helicobacter pylori
- Humans
- Intestinal Absorption
- Iron
(pharmacokinetics)
- Male
- Treatment Outcome
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