Abstract | OBJECTIVES: DESIGN: Prospective cohort study: the Health, Aging and Body Composition Study. SETTING: Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS: MEASUREMENTS: RESULTS: Of the 2,979 participants, 30.1% developed incident mobility limitation. After adjustment for confounders (demographics, prevalent conditions at baseline, body composition), the relative risk (RR) of incident mobility limitation per standard deviation (SD) increase was 1.19 (95% confidence interval (CI)=1.10-1.28) for IL-6, 1.20 (95% CI=1.12-1.29) for TNFalpha, and 1.40 (95% CI=1.18-1.68) for CRP. The association between inflammation and incident mobility limitation was especially strong for the onset of more severe mobility limitation and when the levels of multiple inflammatory markers were high. When persons with baseline or incident cardiovascular disease events or persons who were hospitalized during study follow-up were excluded, findings remained similar. In a subset (n=499), high levels of the soluble receptors IL2sR and TNFsR1 (per SD increase: RR=1.23 (95% CI=1.04-1.46) and RR=1.28 (95% CI=1.04-1.57), respectively) were also associated with incident mobility limitation. CONCLUSION:
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Authors | Brenda W J H Penninx, Stephen B Kritchevsky, Anne B Newman, Barbara J Nicklas, Eleanor M Simonsick, Susan Rubin, Michael Nevitt, Marjolein Visser, Tamara Harris, Marco Pahor |
Journal | Journal of the American Geriatrics Society
(J Am Geriatr Soc)
Vol. 52
Issue 7
Pg. 1105-13
(Jul 2004)
ISSN: 0002-8614 [Print] United States |
PMID | 15209648
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Biomarkers
- Interleukin-6
- Receptors, Cytokine
- Tumor Necrosis Factor-alpha
- C-Reactive Protein
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Topics |
- Aged
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- Female
- Humans
- Inflammation
(blood)
- Interleukin-6
(blood)
- Male
- Pennsylvania
- Prospective Studies
- Receptors, Cytokine
(blood)
- Tennessee
- Tumor Necrosis Factor-alpha
(metabolism)
- Walking
(physiology)
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