Human cancer, PTEN and the PI-3 kinase pathway.

Abstract

The PI-3 kinase pathway is a major driving force for human cancer. One common way of stimulating the PI-3 kinase pathway occurs through inactivation of the PTEN tumor suppressor. The mechanisms of PTEN inactivation include mutation, epigenetic silencing and post-translational modification. Improved insight into the regulation of PTEN is leading to a richer understanding of the contribution of PTEN and the PI-3 kinase pathway to human tumors. Understanding the pathology of PI-3 kinase signaling in tumors improves knowledge of cancer etiology and provides novel therapeutic targets.

• Authors: Ramon Parsons
• Journal: Seminars in cell & developmental biology (Semin Cell Dev Biol) Vol. 15 Issue 2 Pg. 171-6 (Apr 2004) ISSN: 1084-9521 [Print] England
• PMID: 15209376 (Publication Type: Journal Article, Review)

Chemical References

• Tumor Suppressor Proteins
• Phosphatidylinositol 3-Kinases
• Phosphoric Monoester Hydrolases
• PTEN Phosphohydrolase
• PTEN protein, human

Topics

• Animals
• Chromosomes, Human, Pair 10 (genetics)
• Humans
• Neoplasms (enzymology, metabolism, pathology, therapy)
• PTEN Phosphohydrolase
• Phosphatidylinositol 3-Kinases (metabolism)
• Phosphoric Monoester Hydrolases (chemistry, metabolism)
• Signal Transduction
• Tumor Suppressor Proteins (chemistry, metabolism)