[Differentiation of peripheral and central hyperalgesic effects of systemic procaine].

Abstract

OBJECTIVE:

The aim of this study was to differentiate between the peripheral and central analgesic and antihyperalgesic properties of systemic procaine hydrochloride in standardized human pain models.

METHOD:

Subcutaneous injections of either 150 mg procaine hydrochloride or saline solution were administered at intervals of 2 weeks on a randomized and double blind basis. During the 90-min infusion and subsequent 60-min monitoring periods, touch sensitivity was determined and in addition two experimental hyperalgesic models were analyzed.

RESULTS:

While touch sensitivity was not affected by procaine hydrochloride, development of primary mechanical hyperalgesia was significantly reduced.

CONCLUSION:

The concentration of procaine hydrochloride used in our experiment elicited peripheral antihyperalgesic effects without central venous side effects. These results can account for the clinical effect of low-dose procaine hydrochloride in pain conditions exhibiting pronounced hyperalgesia.

• Authors: U Gerdemann, V Brückl, N A S Nassr, D Märkert, R Sittl, W Koppert
• Journal: Schmerz (Berlin, Germany) (Schmerz) Vol. 18 Issue 3 Pg. 189-96 (Jun 2004) ISSN: 0932-433X [Print] Germany
• Vernacular Title: Differenzierung peripherer und zentraler antihyperalgetischer Effekte einer systemischen Procaindauerinfusion.
• PMID: 15206017 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Anesthetics, Local
• Procaine
• Capsaicin

Topics

• Anesthetics, Local (administration & dosage, therapeutic use)
• Capsaicin (administration & dosage)
• Double-Blind Method
• Humans
• Hyperalgesia (drug therapy, physiopathology)
• Infusions, Parenteral
• Injections, Subcutaneous
• Nociceptors (drug effects, physiology)
• Pain Measurement
• Procaine (administration & dosage, therapeutic use)
• Time Factors