Abstract | BACKGROUND: METHODS: RESULTS: It was found that alphaB- crystallin was expressed constitutively in certain breast carcinoma cell lines, including those that were capable of metastasizing in immunodeficient mice. Expression of alphaB- crystallin in human tissue samples was associated strongly with lymph node involvement (P < 0.0001; chi-square test) and, to a lesser degree, with high nuclear grade (P = 0.05). Increased intensity of expression was correlated with shorter survival (P = 0.0091; log-rank test). Multivariate analysis indicated that alphaB- crystallin expression was not independent of lymph node status as a predictor of survival. CONCLUSIONS: The data obtained in the current study revealed a strong association between high expression levels of alphaB- crystallin in primary breast carcinoma specimens and lymph node involvement. Further studies will be needed to prospectively elucidate the role of this novel tumor marker as a clinical prognostic marker in local and locally advanced breast carcinoma as well as its potential status as a new target for therapy in patients with breast carcinoma.
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Authors | Dina Chelouche-Lev, Harriet M Kluger, Aaron J Berger, David L Rimm, Janet E Price |
Journal | Cancer
(Cancer)
Vol. 100
Issue 12
Pg. 2543-8
(Jun 15 2004)
ISSN: 0008-543X [Print] United States |
PMID | 15197794
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Copyright | Copyright 2004 American Cancer Society. |
Chemical References |
- Biomarkers, Tumor
- Crystallins
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Topics |
- Biomarkers, Tumor
- Breast Neoplasms
(metabolism, pathology)
- Carcinoma
(metabolism, pathology)
- Cell Line, Tumor
- Crystallins
(analysis)
- Female
- Humans
- Immunohistochemistry
- Lymphatic Metastasis
- Multivariate Analysis
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