[Photodynamic therapy for choroidal hemangioma. Long-term results].

Abstract

AIM:

Evaluation of functional and anatomical long-term results of patients with symptomatic choroidal hemangioma treated with photodynamic therapy (PDT).

PATIENTS AND METHODS:

All 8 patients suffered from progressive loss of vision caused by exudation into the macular area. PDT with a verteporfin dose of 6 mg/m(2) body surface area and a light dose of 100 J/cm(2) at 692 nm was carried out. Two to four treatments were applied at 6 week intervals using a single laser spot. Standardized evaluation was used before and at 6-week intervals after each treatment and at 3, 6 and 12 months. In the further follow-up control intervals were extended up to 1 year in the case of stable anatomical and functional results.

RESULTS:

All patients showed complete regression of the tumor. The tumor height was reduced from an average of 3.64 mm to undetectable. One patient showed a stable visual acuity, seven patients a significant increase. Central scotometry showed withdrawal of scotomas from the macula. No patient showed any sign of recurrence during the follow-up of up to 60 months.

CONCLUSION:

The long-term results of patients with active choroidal hemangioma demonstrate that PDT is a most effective and safe treatment option. Complete tumor regression is combined with good functional recovery.

• Authors: S Michels, R Michels, A Beckendorf, U Schmidt-Erfurth
• Journal: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft (Ophthalmologe) Vol. 101 Issue 6 Pg. 569-75 (Jun 2004) ISSN: 0941-293X [Print] Germany
• Vernacular Title: Photodynamische Therapie bei chorioidalen Hämangiomen. Langzeitergebnisse.
• PMID: 15197573 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antineoplastic Agents
• Photosensitizing Agents
• Porphyrins
• Verteporfin

Topics

• Adult
• Aged
• Antineoplastic Agents (administration & dosage)
• Choroid Neoplasms (diagnosis, drug therapy)
• Female
• Hemangioma (diagnosis, drug therapy)
• Humans
• Lasers
• Longitudinal Studies
• Male
• Middle Aged
• Neoplasm Recurrence, Local (diagnosis)
• Photochemotherapy (methods)
• Photosensitizing Agents (administration & dosage)
• Porphyrins (administration & dosage)
• Treatment Outcome
• Verteporfin