The pharmacological and pathological studies on Taiwan folk medicine (VII): The anti-inflammatory effect of Echinops grjiisii.

Abstract

The hepatotoxic-protective effects of "San-fang-feng" (the root of E. grijisii) and "Lou-lu" (the root of E. latifolius) on CCl4 induced hepatotoxicity have been proposed in our previous paper (Lin et al, 1990). The anti-inflammatory effects of these two crude drugs were investigated in this experiment. The results indicated that both of them displayed pronounced anti-inflammatory activities against carrageenan-induced edema. Furthermore, in order to isolated the main active components of E. grijisii, fractions obtained from the methanolic extract of E. grijisii were investigated in mice for their 24-h LD50 and 95% confidence limits, which could be used as a guiding for further animal experiments. Our findings demonstrated that n-hexane (100,300 mg/kg), chloroform (30,100, 300 mg/kg) and ethyl acetate (30,100, 300 mg/kg) fractions could markedly inhibit the carrageenan-induced inflammation, and the main active principle was found to be concentrated in the chloroform fraction, which possessed significant inhibitory activities even more than does indomethacin.

• Authors: C C Lin, C H Lin, H F Chiu, M F Hu
• Journal: The American journal of Chinese medicine (Am J Chin Med) Vol. 20 Issue 2 Pg. 127-34 ( 1992) ISSN: 0192-415X [Print] Singapore
• PMID: 1519553 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal

Topics

• Animals
• Drug Evaluation, Preclinical
• Drugs, Chinese Herbal (chemistry, therapeutic use, toxicity)
• Edema (chemically induced, drug therapy)
• Male
• Mice
• Mice, Inbred ICR