WAY100635 and female rat lordosis behavior.

Abstract

Sexually receptive proestrous rats with bilateral cannulae in the ventromedial nucleus of the hypothalamus (VMN) were infused with 200 ng of (+/-)-8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) or with 8-OH-DPAT plus varying concentrations (200 to 2000 ng) of the 5-HT1A receptor antagonist, N-[2[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]N-(2-pyridinyl)cyclohexanecarboxamide trihydrochloride (WAY100635). 8-OH-DPAT inhibited lordosis behavior within 15 min of the infusion and every dose of WAY100635 prevented the inhibition. When non-sexually receptive, ovariectomized rats, hormonally primed with 0.5 microg estradiol benzoate and 500 microg progesterone, were infused with WAY100635 (400 to 2000 ng), the 5-HT1A receptor antagonist did not facilitate lordosis responding. These findings support earlier findings that activation of 5-HT1A receptors in the mediobasal hypothalamus inhibits lordosis behavior. However, they further demonstrate that tonic activation of 5-HT1A receptors is not responsible for the absence of sexual receptivity in suboptimally hormonally primed ovariectomized rats.

• Authors: Lynda Uphouse, Amy Wolf
• Journal: Brain research (Brain Res) Vol. 1013 Issue 2 Pg. 260-3 (Jul 09 2004) ISSN: 0006-8993 [Print] Netherlands
• PMID: 15193537 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Piperazines
• Pyridines
• Serotonin Antagonists
• Serotonin Receptor Agonists
• N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
• 8-Hydroxy-2-(di-n-propylamino)tetralin

Topics

• 8-Hydroxy-2-(di-n-propylamino)tetralin (pharmacology)
• Animals
• Female
• Ovariectomy
• Piperazines (pharmacology)
• Posture
• Proestrus (physiology)
• Pyridines (pharmacology)
• Rats
• Rats, Inbred F344
• Serotonin Antagonists (pharmacology)
• Serotonin Receptor Agonists (pharmacology)
• Sexual Behavior, Animal (drug effects)
• Ventromedial Hypothalamic Nucleus (drug effects, physiology)