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Treatment of Vitiligo with 308-nm xenon-chloride excimer laser: therapeutic efficacy of different initial doses according to treatment areas.

Abstract
Many preliminary data suggest that the 308-nm excimer laser can be a highly effective therapeutic alternative for treating vitiligo, inducing rapid repigmentation with minimal ultraviolet irradiation. We evaluated the clinical efficacy of the 308-nm excimer laser treatment for various body areas, using different initial UV doses. One hundred forty vitiligo patches from 69 patients were assigned to 4 groups; face and neck, trunk, extremities, and acral and joint areas. They were then treated twice a week, using different initial UV doses. The rate of repigmentation continued to increase with the number of treatments up to 20 sessions, and then showed plateaus between 20 to 30 sessions. On the other hand, the lesions in acral and joint areas showed the worst responses throughout the treatment sessions. Our findings extend previous observations that the 308-nm excimer laser is an effective treatment option for patients with vitiligo. However, further studies will be needed to determine the optimal dosing and administration method, especially for acral and joint areas.
AuthorsKwang-Ho Choi, Jung-Hwan Park, Young-Suck Ro
JournalThe Journal of dermatology (J Dermatol) Vol. 31 Issue 4 Pg. 284-92 (Apr 2004) ISSN: 0385-2407 [Print] England
PMID15187323 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Chlorides
  • Xenon
  • xenon chloride
Topics
  • Adolescent
  • Adult
  • Aged
  • Chlorides
  • Female
  • Humans
  • Laser Therapy
  • Male
  • Middle Aged
  • Radiation Dosage
  • Severity of Illness Index
  • Skin Pigmentation (radiation effects)
  • Treatment Outcome
  • Vitiligo (pathology, radiotherapy)
  • Xenon

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