Abstract |
Studies were carried out on the clinical efficacy of panipenem/betamipron ( PAPM/BP) against bacterial infections. The results are summarized as follows: 1. PAPM/BP were administered to total 21 patients (7 cases of pneumonia, 1 case of bronchitis, 3 cases of cellulitis, 2 cases of purulent lymphadenitis, 2 cases of otitis media, 1 case of purulent parotitis, 1 case of sinusitis, 1 case of mastoiditis, 2 cases of urinary tract infection and 1 case of purulent meningitis) by drip intravenous injection. 2. Clinical responses of PAPM/BP were excellent in 12 cases, good in 7, poor in 1 and unknown in 1 case. The overall efficacy rate was 95.0%. 3. Concentration of PAPM in cerebrospinal fluid after 1 hour drip intravenous administration in 1 case of purulent meningitis were 6.84 micrograms/ml at the acute stage and 3.28 micrograms/ml at the recovering stage. 4. Neither side effects nor abnormal laboratory findings were observed except 1 case of increase of thrombocytosis out of 19 cases. 5. From the results, PAPM/BP was determined to be an efficacious and safe drug for the therapy of pediatric infection.
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Authors | S Furukawa, T Okada |
Journal | The Japanese journal of antibiotics
(Jpn J Antibiot)
Vol. 45
Issue 4
Pg. 424-9
(Apr 1992)
ISSN: 0368-2781 [Print] Japan |
PMID | 1518125
(Publication Type: Clinical Trial, English Abstract, Journal Article)
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Chemical References |
- Thienamycins
- beta-Alanine
- panipenem-betamipron
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Topics |
- Adolescent
- Age Factors
- Bacteria
(drug effects, isolation & purification)
- Bacterial Infections
(drug therapy, microbiology)
- Child
- Child, Preschool
- Drug Evaluation
- Drug Resistance, Microbial
- Drug Therapy, Combination
(cerebrospinal fluid, pharmacology, therapeutic use)
- Female
- Humans
- Infant
- Male
- Meningitis
(cerebrospinal fluid)
- Suppuration
- Thienamycins
(cerebrospinal fluid, pharmacology, therapeutic use)
- beta-Alanine
(analogs & derivatives, cerebrospinal fluid, pharmacology, therapeutic use)
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