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[Clinical evaluation of panipenem/betamipron in pediatrics].

Abstract
Studies were carried out on the clinical efficacy of panipenem/betamipron (PAPM/BP) against bacterial infections. The results are summarized as follows: 1. PAPM/BP were administered to total 21 patients (7 cases of pneumonia, 1 case of bronchitis, 3 cases of cellulitis, 2 cases of purulent lymphadenitis, 2 cases of otitis media, 1 case of purulent parotitis, 1 case of sinusitis, 1 case of mastoiditis, 2 cases of urinary tract infection and 1 case of purulent meningitis) by drip intravenous injection. 2. Clinical responses of PAPM/BP were excellent in 12 cases, good in 7, poor in 1 and unknown in 1 case. The overall efficacy rate was 95.0%. 3. Concentration of PAPM in cerebrospinal fluid after 1 hour drip intravenous administration in 1 case of purulent meningitis were 6.84 micrograms/ml at the acute stage and 3.28 micrograms/ml at the recovering stage. 4. Neither side effects nor abnormal laboratory findings were observed except 1 case of increase of thrombocytosis out of 19 cases. 5. From the results, PAPM/BP was determined to be an efficacious and safe drug for the therapy of pediatric infection.
AuthorsS Furukawa, T Okada
JournalThe Japanese journal of antibiotics (Jpn J Antibiot) Vol. 45 Issue 4 Pg. 424-9 (Apr 1992) ISSN: 0368-2781 [Print] Japan
PMID1518125 (Publication Type: Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Thienamycins
  • beta-Alanine
  • panipenem-betamipron
Topics
  • Adolescent
  • Age Factors
  • Bacteria (drug effects, isolation & purification)
  • Bacterial Infections (drug therapy, microbiology)
  • Child
  • Child, Preschool
  • Drug Evaluation
  • Drug Resistance, Microbial
  • Drug Therapy, Combination (cerebrospinal fluid, pharmacology, therapeutic use)
  • Female
  • Humans
  • Infant
  • Male
  • Meningitis (cerebrospinal fluid)
  • Suppuration
  • Thienamycins (cerebrospinal fluid, pharmacology, therapeutic use)
  • beta-Alanine (analogs & derivatives, cerebrospinal fluid, pharmacology, therapeutic use)

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