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Amantadine in the akinetic-rigid variant of Huntington's disease.

AbstractOBJECTIVE:
To report the effects of amantadine on an akinetic-rigid variant of Huntington's disease (HD).
CASE SUMMARY:
We describe a 36-year-old woman with HD who was treated with intravenous amantadine for 5 days. The woman was evaluated with the Unified Huntington's Disease Rating Scale before and after treatment. Parkinsonism, bradykinesia, and dystonia improved significantly.
DISCUSSION:
Amantadine is a noncompetitive N-methyl d-aspartate receptor antagonist. It is mainly used in the treatment of Parkinson's disease, as it increases dopamine levels in the brain. This effect is said to ameliorate akinesia. Although the effect of amantadine on choreatic dystonia in HD has been reported in several studies, to the best of our knowledge, this is the first report of the ameliorative effects of amantadine on the rigid form of HD. Our patient showed improvements of gait, parkinsonism, and dystonia. Fine-motor tasks and eye movement did not change significantly.
CONCLUSIONS:
We suggest that amantadine treatment might be of value to patients with the akinetic-rigid variant of HD.
AuthorsMarkus K Magnet, Raphael M Bonelli, Hans-Peter Kapfhammer
JournalThe Annals of pharmacotherapy (Ann Pharmacother) 2004 Jul-Aug Vol. 38 Issue 7-8 Pg. 1194-6 ISSN: 1060-0280 [Print] United States
PMID15178736 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antiparkinson Agents
  • Amantadine
Topics
  • Adult
  • Amantadine (therapeutic use)
  • Antiparkinson Agents (therapeutic use)
  • Female
  • Humans
  • Huntington Disease (drug therapy)

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