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Hemophagocytic syndrome as a presenting sign of transformation of smoldering to acute adult T-cell leukemia/lymphoma: efficacy of anti-retroviral and interferon therapy.

Abstract
A 55-year-old Caribbean woman with a 6-year history of smoldering adult T-cell leukemia/lymphoma presented with clinical and biological symptoms of hemophagocytic syndrome. An extensive search for infectious diseases was negative. A lymph node biopsy showing large T-cell lymphoma (CD4-, CD25+) and findings of high LDH count and severe lymphocytosis led to the diagnosis of acute adult T-cell leukemia/lymphoma. Anti-retroviral therapy combining zidovudine, lamivudine, and interferon-alpha was started, resulting in rapid control of both hemophagocytic syndrome and symptoms of acute adult T-cell leukemia/lymphoma. Thus, we propose that adult T-cell leukemia/lymphoma must be added to the spectrum of etiologies of hemophagocytic syndrome.
AuthorsAchille Aouba, Olivier Lambotte, Viorel Vasiliu, Marine Divine, Françoise Valensi, Bruno Varet, Ali Bazarbachi, Olivier Hermine
JournalAmerican journal of hematology (Am J Hematol) Vol. 76 Issue 2 Pg. 187-9 (Jun 2004) ISSN: 0361-8609 [Print] United States
PMID15164389 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright 2004 Wiley-Liss, Inc.
Chemical References
  • Antineoplastic Agents
  • Antiviral Agents
  • Interferon-alpha
  • Lamivudine
  • Zidovudine
Topics
  • Antineoplastic Agents (therapeutic use)
  • Antiviral Agents (therapeutic use)
  • Drug Therapy, Combination
  • Female
  • Histiocytosis (etiology)
  • Humans
  • Interferon-alpha (therapeutic use)
  • Lamivudine (therapeutic use)
  • Leukemia-Lymphoma, Adult T-Cell (drug therapy, pathology)
  • Middle Aged
  • Zidovudine (therapeutic use)

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