Abstract | OBJECTIVE: METHODS: Mean arterial blood pressure, and blood flow in the portal vein, hepatic artery, and hindquarter vascular beds were measured in 49 halothane anaesthetised New Zealand White rabbits given lipopolysaccharide (Salmonella minnesota, 500 micrograms.kg-1 intravenously). The effects of pre- or post- lipopolysaccharide treatment with L-NMMA (300 mg.kg-1 intravenously) and of pretreatment with dexamethasone (3 mg.kg-1 intravenously) were determined. The effect of the NO donor S-nitroso-N-acetyl- penicillamine (SNAP, 300 micrograms.kg-1.h-1 intravenously) in animals treated with lipopolysaccharide and L-NMMA was also studied. RESULTS: CONCLUSIONS: Inhibition of both constitutive and inducible NO synthases during endotoxaemia is deleterious. This can be overcome by replacing NO intravenously with a donor of NO. Selective inhibition of the inducible NO synthase may, however, be beneficial in shock.
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Authors | C E Wright, D D Rees, S Moncada |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 26
Issue 1
Pg. 48-57
(Jan 1992)
ISSN: 0008-6363 [Print] England |
PMID | 1516112
(Publication Type: Journal Article)
|
Chemical References |
- omega-N-Methylarginine
- Nitric Oxide
- S-Nitroso-N-Acetylpenicillamine
- Dexamethasone
- Arginine
- Penicillamine
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Topics |
- Animals
- Arginine
(analogs & derivatives, pharmacology)
- Blood Pressure
(drug effects)
- Dexamethasone
(pharmacology)
- Disease Models, Animal
- Heart Rate
(drug effects)
- Male
- Nitric Oxide
(metabolism)
- Penicillamine
(analogs & derivatives, pharmacology)
- Rabbits
- Regional Blood Flow
(drug effects)
- S-Nitroso-N-Acetylpenicillamine
- Shock, Septic
(metabolism)
- omega-N-Methylarginine
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