Abstract |
The present study was performed to assess the expression of isoforms 1, 2 and 3 of transforming growth factor ( TGF)-beta in skin nodular dermatofibrosis lesions, kidney, bladder and pancreas from a 10-year-old female German shepherd dog (GSD) affected by renal cystadenocarcinoma and nodular dermatofibrosis (RCND) compared with normal GSDs (n = 2). Formalin-fixed, paraffin-embedded tissues obtained from the dog affected by RCND, diagnosed by renal ultrasonography and histopathological examination were analysed by immunohistochemistry using polyclonal antibodies to TGF-beta1, 2 and 3, and evaluated semiquantitatively using an immunoreactivity score. Similar expression of TGF-beta2 and TGF-beta3 was observed in all tissue specimens in both the RCND-affected animal and normal dogs. In contrast, TGF-beta1 immunoreactivity was increased in the derma of the RCND canine. Comparable TGF-beta1 serum levels were found between the diseased and normal animals. The increased local cutaneous production of TGF-beta1 in the RCND dog, compared with the normal animals, suggests that this cytokine may play an important role in the induction of nodular dermatofibrosis associated with renal cystadenocarcinoma.
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Authors | A Vercelli, G Bellone, O Abate, G Emanuelli, A Cagnasso |
Journal | Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
(J Vet Med A Physiol Pathol Clin Med)
Vol. 50
Issue 10
Pg. 506-10
(Dec 2003)
ISSN: 0931-184X [Print] Germany |
PMID | 15157018
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Transforming Growth Factor beta
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Topics |
- Animals
- Case-Control Studies
- Cystadenocarcinoma
(complications, veterinary)
- Dog Diseases
(metabolism)
- Dogs
- Female
- Histiocytoma, Benign Fibrous
(complications, metabolism, veterinary)
- Immunohistochemistry
(veterinary)
- Kidney
(metabolism)
- Kidney Neoplasms
(complications, veterinary)
- Pancreas
(metabolism)
- Skin
(metabolism)
- Skin Neoplasms
(complications, metabolism, veterinary)
- Transforming Growth Factor beta
(blood, metabolism)
- Urinary Bladder
(metabolism)
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