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T cell receptor delta-chain gene rearrangement in a novel case of adult NK cell leukemia.

Abstract
Malignancies arising from natural killer (NK) cells are being increasingly recognized as distinct clinicopathological entities. We here report the characteristics of a peculiar case of NK-cell acute leukemia with unusual agranular morphology and rearrangement of the T-cell receptor (TCR) delta-chain gene.
AuthorsFabio Stagno, Patrizia Guglielmo, Luca Lo Nigro, Annamaria Santonocito, Rosario Giustolisi
JournalActa haematologica (Acta Haematol) Vol. 111 Issue 4 Pg. 225-7 ( 2004) ISSN: 0001-5792 [Print] Switzerland
PMID15153716 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright 2004 S. Karger AG, Basel
Chemical References
  • Antigens, CD
Topics
  • Acute Disease
  • Aged
  • Antigens, CD (analysis)
  • Bone Marrow Examination
  • Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
  • Genes, T-Cell Receptor delta (genetics)
  • Humans
  • Killer Cells, Natural (pathology, ultrastructure)
  • Leukemia, Lymphoid (genetics, pathology)
  • Leukemia, T-Cell (genetics, pathology)
  • Male

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