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The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation.

Abstract
We have identified that StarD10, a member of the START protein family, is overexpressed in both mouse and human breast tumors. StarD10 was initially discovered on the basis of its cross-reactivity with a phosphoserine-specific antibody in mammary tumors from Neu/ErbB2 transgenic mice and subsequently isolated from SKBR3 human breast carcinoma cells using a multistep biochemical purification strategy. We have shown that StarD10 is capable of binding lipids. StarD10 was found to be overexpressed in 35% of primary breast carcinomas and 64% of human breast cancer cell lines, correlating with their ErbB2/Her2 status. Coexpression of StarD10 with ErbB1/epidermal growth factor receptor in murine fibroblasts enhanced anchorage-independent growth in soft agar, providing evidence for functional cooperation between StarD10 and ErbB receptor signaling. Taken together, these data suggest that overexpression of this lipid-binding protein contributes to breast oncogenesis.
AuthorsMonilola A Olayioye, Peter Hoffmann, Thomas Pomorski, Jane Armes, Richard J Simpson, Bruce E Kemp, Geoffrey J Lindeman, Jane E Visvader
JournalCancer research (Cancer Res) Vol. 64 Issue 10 Pg. 3538-44 (May 15 2004) ISSN: 0008-5472 [Print] United States
PMID15150109 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Forkhead Box Protein O1
  • Forkhead Transcription Factors
  • Foxo1 protein, mouse
  • Phosphoproteins
  • STARD10 protein, human
  • Stard10 protein, mouse
  • Transcription Factors
  • ErbB Receptors
  • Receptor, ErbB-2
Topics
  • Amino Acid Sequence
  • Animals
  • Antibody Specificity
  • Breast Neoplasms (metabolism, pathology)
  • Cell Line, Tumor
  • Cell Transformation, Neoplastic (metabolism, pathology)
  • Cross Reactions
  • ErbB Receptors (biosynthesis, metabolism)
  • Forkhead Box Protein O1
  • Forkhead Transcription Factors
  • Humans
  • Mammary Neoplasms, Experimental (metabolism, pathology)
  • Mice
  • Molecular Sequence Data
  • Molecular Weight
  • Phosphoproteins (biosynthesis, chemistry, metabolism)
  • Receptor, ErbB-2 (biosynthesis, metabolism)
  • Sequence Homology, Amino Acid
  • Transcription Factors (chemistry, immunology)

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