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Preimplantation genetic diagnosis in patients with male meiotic abnormalities.

Abstract
Indications and candidates for preimplantation genetic diagnosis (PGD) have increased in recent years. This study evaluates whether IVF-intracytoplasmic sperm injection (ICSI) results could be improved by selecting embryos through PGD-AS (aneuploidy screening) in couples in whom the male partner presents meiotic abnormalities. Two hundred and fifty-six embryos were biopsied and 183 were suitable for analysis (73.2%). Ninety-two embryos showed normal chromosomal analysis (50.3% of the analysed embryos and 57.5% of the diagnosed embryos). Pregnancy, abortion and implantation rates were compared with 66 IVF-ICSI cycles performed in 44 patients with meiotic abnormalities without PGD (control group). No statistically significant differences in the pregnancy rate (52 versus 43.9%), implantation rate (32.1 versus 23.5%) and miscarriage rate (15.4 versus 10.3%) were observed between the groups. Although the embryos obtained from men with meiotic abnormalities showed a high frequency of chromosome abnormalities, no improvements in pregnancy and implantation rates were obtained after PGD-AS in the series analysed.
AuthorsB Aran, A Veiga, F Vidal, M Parriego, J M Vendrell, J Santaló, J Egozcue, P N Barri
JournalReproductive biomedicine online (Reprod Biomed Online) Vol. 8 Issue 4 Pg. 470-6 (Apr 2004) ISSN: 1472-6483 [Print] Netherlands
PMID15149574 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Abortion, Spontaneous (epidemiology)
  • Chromosome Aberrations
  • Embryo Implantation
  • Female
  • Fertilization in Vitro
  • Humans
  • Incidence
  • Male
  • Meiosis
  • Pregnancy
  • Pregnancy Rate
  • Preimplantation Diagnosis
  • Sperm Injections, Intracytoplasmic
  • Spermatozoa (abnormalities, cytology)

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