Abstract |
Indications and candidates for preimplantation genetic diagnosis ( PGD) have increased in recent years. This study evaluates whether IVF-intracytoplasmic sperm injection (ICSI) results could be improved by selecting embryos through PGD-AS ( aneuploidy screening) in couples in whom the male partner presents meiotic abnormalities. Two hundred and fifty-six embryos were biopsied and 183 were suitable for analysis (73.2%). Ninety-two embryos showed normal chromosomal analysis (50.3% of the analysed embryos and 57.5% of the diagnosed embryos). Pregnancy, abortion and implantation rates were compared with 66 IVF-ICSI cycles performed in 44 patients with meiotic abnormalities without PGD (control group). No statistically significant differences in the pregnancy rate (52 versus 43.9%), implantation rate (32.1 versus 23.5%) and miscarriage rate (15.4 versus 10.3%) were observed between the groups. Although the embryos obtained from men with meiotic abnormalities showed a high frequency of chromosome abnormalities, no improvements in pregnancy and implantation rates were obtained after PGD-AS in the series analysed.
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Authors | B Aran, A Veiga, F Vidal, M Parriego, J M Vendrell, J Santaló, J Egozcue, P N Barri |
Journal | Reproductive biomedicine online
(Reprod Biomed Online)
Vol. 8
Issue 4
Pg. 470-6
(Apr 2004)
ISSN: 1472-6483 [Print] Netherlands |
PMID | 15149574
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Abortion, Spontaneous
(epidemiology)
- Chromosome Aberrations
- Embryo Implantation
- Female
- Fertilization in Vitro
- Humans
- Incidence
- Male
- Meiosis
- Pregnancy
- Pregnancy Rate
- Preimplantation Diagnosis
- Sperm Injections, Intracytoplasmic
- Spermatozoa
(abnormalities, cytology)
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