[A case of acute cardiac insufficiency caused by 5-fluorouracil].

Abstract

The authors report a case of acute cardiac failure linked to 5 fluoro-uracil. The toxicity seen most commonly involves ischemia. The pathophysiological mechanisms are discussed as well as the role played by pharmacokinetic characteristics in the occurrence of adverse reactions. 5 fluoro-uracil (5 FU) is a compound widely used in the treatment of ENT, breast and gastrointestinal carcinomas. The finding of dose-effect relationship may lead the clinician to use different modes of administration. Continuous administration at high dose 3 g/m2/day from D1 to D5) in combination or not with cisplatin, or continuously at low dose (300 mg/m2/day from D1 to D31) can reduce hematopoietic toxicity but, in contrast, increases gastrointestinal toxicity.

• Authors: J P Fauchart, J M Favriel, R Fallouh, L Chapoutot, L Bailly
• Journal: Annales de gastroenterologie et d'hepatologie (Ann Gastroenterol Hepatol (Paris)) 1992 May-Jul Vol. 28 Issue 3 Pg. 117-9 ISSN: 0066-2070 [Print] France
• Vernacular Title: Un cas d'insuffisance cardiaque aiguë due au 5 fluoro-uracile.
• PMID: 1514765 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Diuretics
• Digoxin
• Fluorouracil

Topics

• Adenocarcinoma (drug therapy)
• Cardiac Output, Low (chemically induced, diagnosis, drug therapy)
• Digoxin (therapeutic use)
• Diuretics (therapeutic use)
• Echocardiography, Doppler
• Electrocardiography
• Female
• Fluorouracil (administration & dosage, adverse effects, pharmacokinetics)
• Humans
• Middle Aged
• Sigmoid Neoplasms (drug therapy)