[An experimental study of the therapeutic effect of interleukin-2 and interleukin-12 with and without amphotericin B on pulmonary fungal infection].

Abstract

OBJECTIVE:

To study the therapeutic effect of interleukin-2 (IL-2) and interleukin-12 (IL-12) with and without amphotericin B on pulmonary fungal infection of mice.

METHODS:

A mouse model of pulmonary invasive aspergillus fumigatus (IPA) infection was established and the mice were divided into different groups, treated with IL-2 and IL-12 with and without amphotericin B. The survival number of mice in 15 days and the colony count of lung tissue in the different groups were observed.

RESULTS:

IL-2, IL-12 and amphotericin B showed synergistic effect in prolonging the survival of the infected mice and reducing the colony count in the lung tissue.

CONCLUSION:

IL-2 and IL-12 are effective adjuvant therapeutic agents in the immunosuppressed hosts.

• Authors: Chang-ran Zhang, Ying-chun Tang, K Kawakami, Tian-tuo Zhang, Kou-xing Zhang, Jia-xin Zhu
• Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases (Zhonghua Jie He He Hu Xi Za Zhi) Vol. 27 Issue 4 Pg. 234-6 (Apr 2004) ISSN: 1001-0939 [Print] China
• PMID: 15144612 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Interleukin-2
• Interleukin-12
• Amphotericin B

Topics

• Amphotericin B (therapeutic use)
• Animals
• Antifungal Agents (therapeutic use)
• Aspergillosis (drug therapy)
• Aspergillus fumigatus (isolation & purification)
• Colony Count, Microbial
• Drug Synergism
• Interleukin-12 (therapeutic use)
• Interleukin-2 (therapeutic use)
• Lung Diseases, Fungal (drug therapy)
• Male
• Mice
• Mice, Inbred BALB C
• Random Allocation