[An experimental study(II) on the inhibition of prostatic hyperplasia by extract of seeds of Brassica alba].

Abstract

OBJECTIVE:

To study the active components and their functionary mechanism of the extract of Brassica alba seeds, which inhibits experimental mice prostatic hyperplasia.

METHOD:

Prostatic hyperplasia of castrated male mice induced by testosterone propionate, the penetrability of capillary vessel of mice skin induced by histamine and the endermic flesh bud of rat induced by filter paper were used as experimental models. Sinalbin and beta-sitosterol separated from seeds of Brassica alba were used to test the activities.

RESULT:

Sinalbin and beta-sitosterol(16.0 mg.kg-1.d-1 and 8.0 mg.kg-1.d-1) could significantly inhibit mice prostatic hyperplasia induced by testosterone propionate and activity of serum acid phosphatase(P < 0.01 or P < 0.05), Sinalbin(16.0 mg.kg-1.d-1)could significantly inhibit the hyperplasia of endermic flesh bud in rat induced by filter paper(P < 0.05), beta-sitosterol(16.0 mg.kg-1.d-1 and 8.0 mg.kg-1.d-1) could significantly decrease the penetrability of capillary vessel of mice skin induced by histamine.

CONCLUSION:

Sinalbin and beta-sitosterol have anti-androgen and anti-inflammation activities.

• Authors: Guo-xin Wu, Yue-xin Lin, Min-rui Ou, Dong-fei Tan
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 28 Issue 7 Pg. 643-6 (Jul 2003) ISSN: 1001-5302 [Print] China
• PMID: 15139111 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Androgen Antagonists
• Anti-Inflammatory Agents, Non-Steroidal
• Sitosterols
• gamma-sitosterol
• Choline
• Testosterone Propionate
• sinalbin

Topics

• Androgen Antagonists (pharmacology)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Capillary Permeability (drug effects)
• Choline (analogs & derivatives, isolation & purification, pharmacology)
• Female
• Male
• Mice
• Mustard Plant (chemistry)
• Orchiectomy
• Plants, Medicinal (chemistry)
• Prostatic Hyperplasia (blood, chemically induced, physiopathology)
• Rats
• Rats, Sprague-Dawley
• Seeds (chemistry)
• Sitosterols (isolation & purification, pharmacology)
• Testosterone Propionate