[C-peptide and insulin ratio in patients with juvenile dyspituitarism in varying symptomatology].

Abstract

Altogether 24 adolescents with pubertal juvenile dyspituitarism (PJD) were investigated in the course of an oral GTT for 3 hours. The patients were divided into 3 groups: (1) with liver dysfunction and normal BP; (2) with normal liver and arterial hypertension; (3) with normal BP and normal liver function. The levels of glycemia, immunoreactive insulin, C-peptide and a molar C-peptide/insulin ratio were measured. All the examinees were characterized by basal and stimulated hyperinsulinemia against a background of a normal C-peptide value, the absence of a tendency to IRI reduction by the end of the GTT. A decrease in the C-peptide/IRI ratio was marked in the 1st group. One of the reasons of hyperinsulinemia in PJD in parallel with high insulin secretory pancreatic function can be a decrease in the metabolic clearance of liver insulin, especially noticeable in patients with hepatocyte dysfunction.

• Authors: E V Malygina, I M Belovalova, N T Starkova, L K Starosel'tseva
• Journal: Problemy endokrinologii (Probl Endokrinol (Mosk)) 1992 Mar-Apr Vol. 38 Issue 2 Pg. 17-20 ISSN: 0375-9660 [Print] Russia (Federation)
• Vernacular Title: Sootnoshenie C-peptida i insulina u bol'nykh s iunosheskim dispituitarizmom pri razlichnoĭ klinicheskoĭ simptomatike.
• PMID: 1513765 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Blood Glucose
• C-Peptide
• Insulin

Topics

• Adolescent
• Adult
• Blood Glucose (metabolism)
• Blood Pressure (physiology)
• C-Peptide (blood)
• Glucose Tolerance Test
• Humans
• Hypertension (blood)
• Insulin (blood, pharmacokinetics)
• Liver Diseases (blood)
• Metabolic Clearance Rate (physiology)
• Pituitary Diseases (blood)
• Reference Values