Abstract | BACKGROUND: METHODS: RESULTS: Anti- integrin antibody significantly decreased the weight of port-site metastatic tumors without hyaluronic acid (control vs anti- integrin: 8.2 +/- 7.1 vs 3.6 +/- 4.5 mg; p < 0.05) but not the frequency of port-site metastases. With hyaluronic acid, the frequency of port-site metastasis and the weight of port-site metastatic tumors were significantly decreased both by anti- integrin and by anti-CD44 antibody (control vs anti- integrin and anti-CD44; 95% and 8.5 +/- 7.2 mg vs 50% and 3.1 +/- 4.3 mg and 55% and 3.3 +/- 5.1 mg, respectively; p < 0.05). RGD peptide and FC-336 also inhibited port-site metastasis in a dose-dependent manner. CONCLUSION:
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Authors | Y Hirabayashi, K Yamaguchi, N Shiraishi, Y Adachi, I Saiki, S Kitano |
Journal | Surgical endoscopy
(Surg Endosc)
Vol. 18
Issue 7
Pg. 1113-7
(Jul 2004)
ISSN: 1432-2218 [Electronic] Germany |
PMID | 15136928
(Publication Type: Journal Article)
|
Chemical References |
- Antibodies, Monoclonal
- Cell Adhesion Molecules
- FC 336
- Hyaluronan Receptors
- Integrins
- Oligopeptides
- Carbon Dioxide
- arginyl-glycyl-aspartic acid
- Hyaluronic Acid
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Topics |
- Animals
- Antibodies, Monoclonal
(administration & dosage, immunology, therapeutic use)
- Antibody Specificity
- Carbon Dioxide
(administration & dosage)
- Carcinoma
(pathology)
- Cell Adhesion Molecules
(antagonists & inhibitors, physiology)
- Cell Line, Tumor
(transplantation)
- Drug Evaluation, Preclinical
- Drug Synergism
- Female
- Humans
- Hyaluronan Receptors
(immunology)
- Hyaluronic Acid
(administration & dosage, therapeutic use)
- Injections, Intraperitoneal
- Integrins
(immunology)
- Mice
- Mice, Inbred BALB C
- Neoplasm Seeding
- Neoplasm Transplantation
- Oligopeptides
(administration & dosage, therapeutic use)
- Pneumoperitoneum, Artificial
(adverse effects)
- Stomach Neoplasms
(pathology)
- Transplantation, Heterologous
- Tumor Burden
(drug effects)
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