Efficacy of pyrimethamine-sulfadoxine in young children with uncomplicated falciparum malaria in rural Burkina Faso.

Abstract

The efficacy of pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in young children of a malaria holoendemic area in rural Burkina Faso is reported. Of 28 children treated with a standard single dose of pyrimethamine-sulfadoxine and followed-up over 14 days, only one Late Treatment Failure and four Late Parasitological Failures were observed, all with low-grade parasitaemia. In this area of very restricted use of pyrimethamine-sulfadoxine, the drug appears to be still sufficiently effective in the treatment of malaria. These findings provide further evidence for the justification of continued use of pyrimethamine-sulfadoxine as a second-line treatment for malaria in Burkina Faso.

• Authors: Olaf Müller, Corneille Traore, Bocar Kouyate
• Journal: Malaria journal (Malar J) Vol. 3 Pg. 10 (May 11 2004) ISSN: 1475-2875 [Electronic] England
• PMID: 15134583 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimalarials
• Drug Combinations
• fanasil, pyrimethamine drug combination
• Sulfadoxine
• Pyrimethamine

Topics

• Antimalarials (therapeutic use)
• Burkina Faso
• Child, Preschool
• Cohort Studies
• Drug Combinations
• Female
• Humans
• Infant
• Malaria, Falciparum (diagnosis, drug therapy)
• Male
• Parasitemia (diagnosis, drug therapy)
• Pyrimethamine (therapeutic use)
• Sulfadoxine (therapeutic use)
• Treatment Outcome