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Increased repetitive behaviours and prolactin responsivity to oral m-chlorophenylpiperazine in adults with autism spectrum disorders.

Abstract
Autism is a neurodevelopmental disorder characterized by dysfunction in three primary behavioural domains: repetitive behaviours, social deficits, and language abnormalities. There is evidence that abnormalities exist in the serotonin (5-HT) system in autism spectrum patients. Furthermore, 5-HT is known to play a role in repetitive and social behaviours. This study examined the effect of m-chlorophenylpiperazine (m-CPP) on repetitive behaviours and prolactin response in 11 adults with autism or Aspergers disorder and 8 age- and gender-matched healthy controls via randomized double-blind, m-CPP and placebo challenges. The primary outcome measure was an instrument rating six repetitive behaviours: need to know, repeating, ordering, need to tell/ask, self-injury, and touching. Patients with autism spectrum disorders showed a significant increase in repetitive behaviours at end-point following oral m-CPP in comparison to placebo. Additionally subjects with autism spectrum disorders showed a significantly increased prolactin response to m-CPP compared to normal controls, with neither group responding to placebo. This study provides further evidence for altered 5-HT sensitivity in individuals with autism spectrum disorders, as well as a possible relationship between repetitive behaviours in autism spectrum disorders and abnormalities in the 5-HT system.
AuthorsSherie Novotny, Eric Hollander, Ann Phillips, Andrea Allen, Stacey Wasserman, Rupa Iyengar
JournalThe international journal of neuropsychopharmacology (Int J Neuropsychopharmacol) Vol. 7 Issue 3 Pg. 249-54 (Sep 2004) ISSN: 1461-1457 [Print] England
PMID15132762 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Piperazines
  • Serotonin Receptor Agonists
  • Prolactin
  • 1-(3-chlorophenyl)piperazine
Topics
  • Adolescent
  • Adult
  • Asperger Syndrome (blood, psychology)
  • Autistic Disorder (blood, psychology)
  • Behavior (drug effects)
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Piperazines (pharmacology)
  • Prolactin (blood)
  • Serotonin Receptor Agonists (pharmacology)
  • Social Behavior

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