Attenuation of dysfunction in the ischemia-reperfused liver by glycyrrhizin.

Abstract	The present study evaluated the effect of glycyrrhizin (GR) on an injury of the liver caused by ischemia-reperfusion in rats. In the liver ischemia-reperfusion model, levels of serum GOT, GPT and LDH activities and lipid peroxides in the liver tissue were significantly increased. On the contrary, total glutathione content in the liver tissue and NADPH cytochrome P-450 reductase activity of liver microsomes were decreased. Pretreatment with GR 20 mg/kg, i.v. 10 min before induction of ischemia resulted in significant decreases in serum GOT, GPT, LDH activities and the lipid peroxide level and a higher tissue glutathione content during the period of reperfusion. Electron microscopic studies revealed various hepatocellular damages with an almost intact sinusoidal endothelium in ischemia-reperfused livers. However, the degree of damage was less severe in the livers from the rats pretreated with 20 mg/kg GR. The results indicate that GR is able to provide partial protection against ischemia-reperfused damage.
Authors	T Nagai, T Egashira, Y Kudo, Y Yamanaka, T Shimada
Journal	Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 58 Issue 3 Pg. 209-18 (Mar 1992) ISSN: 0021-5198 [Print] Japan
PMID	1513071 (Publication Type: Journal Article)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Enzymes Lipid Peroxides Proteins Glycyrrhizic Acid Cytochromes b5 Cytochrome P-450 Enzyme System NADPH-Ferrihemoprotein Reductase Glutathione Glycyrrhetinic Acid
Topics	Animals Anti-Inflammatory Agents, Non-Steroidal (therapeutic use) Cytochrome P-450 Enzyme System (metabolism) Cytochromes b5 (metabolism) Enzymes (blood) Glutathione (metabolism) Glycyrrhetinic Acid (analogs & derivatives, therapeutic use) Glycyrrhizic Acid Ischemia (drug therapy, pathology, physiopathology) Lipid Peroxides (metabolism) Liver (pathology) Liver Circulation (drug effects) Male Microscopy, Electron Microsomes (drug effects, enzymology) NADPH-Ferrihemoprotein Reductase (metabolism) Proteins (metabolism) Rats Rats, Inbred Strains Reperfusion Injury (drug therapy, pathology, physiopathology)

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