Abstract | PURPOSE: We evaluated patients with interstitial cystitis who had been on cyclosporine A treatment for at least a year. Symptom improvement on micturition charts and subjective expression of bladder pain were recorded. Side effects and safety of medication were evaluated. MATERIALS AND METHODS: A total of 23 patients (20 females and 3 males) fulfilling National Institute for Diabetes and Digestive and Kidney Diseases criteria of interstitial cystitis were included in this study. Age of patients at followup was 65.7 +/- 7.6 years (mean +/- SD). Mean followup was 60.8 +/- 35.7 months. Before starting cyclosporine A treatment multiple first line therapies had been tried without clinical help. RESULTS: The number of voidings in 24 hours was 20.8 +/- 6.3 before treatment. After a year of cyclosporine A treatment it was decreased to 10.2 +/- 3.8 (p < 0.001). Maximal bladder capacity increased from 161.8 +/- 74.6 to 360.7 +/- 99.3 ml in a year (p < 0.001). Mean voided volume increased from 101.4 +/- 42.7 to 246.4 +/- 97.9 ml (p < 0.001). The effect was maintained throughout followup. Of 23 total patients 20 reported no bladder pain on cyclosporine A treatment and 11 patients stopped treatment due to a good clinical effect. In 9 patients symptoms recurred within months but disappeared again after cyclosporine A treatment was restarted. Side effects of medication were infrequent. CONCLUSIONS:
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Authors | Jukka Sairanen, Tapio Forsell, Mirja Ruutu |
Journal | The Journal of urology
(J Urol)
Vol. 171
Issue 6 Pt 1
Pg. 2138-41
(Jun 2004)
ISSN: 0022-5347 [Print] United States |
PMID | 15126772
(Publication Type: Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Cyclosporine
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Topics |
- Aged
- Aged, 80 and over
- Cyclosporine
(administration & dosage)
- Cystitis, Interstitial
(drug therapy)
- Female
- Humans
- Immunosuppressive Agents
(administration & dosage)
- Male
- Middle Aged
- Time Factors
- Treatment Outcome
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