CO-N reaction--a new serological activity index--on Wegener's granulomatosis.

Abstract

Cordyceps ophioglossoides is one of the Japanese old 'Kanpoh' drugs used for metrorrhagia as a decoction. We found that CO-N, a galactosaminoglycan from Cordyceps ophioglossoides, reacted with sera from patients with some collagen diseases. By using CO-N, we made a new serological activity index (CO-N reaction). In the present study, we investigated CO-N reaction on patients with Wegener's granulomatosis (WG). The aggregation titres of CO-N (CO-N numbers) displayed a possible correlation with their clinical activity. CO-N reaction might also serve an important role in supporting the diagnosis of active WG and in helping to assess the degree of disease activity. The purpose of this report is to introduce this new serological activity index for Wegener's granulomatosis.

• Authors: M Ikeda, S Tsuru, T Ohmori, S Kitahara, T Inouye, G B Healy
• Journal: The Journal of laryngology and otology (J Laryngol Otol) Vol. 107 Issue 7 Pg. 607-10 (Jul 1993) ISSN: 0022-2151 [Print] England
• PMID: 15125278 (Publication Type: Journal Article)

Chemical References

• Polysaccharides
• galactosaminoglycan

Topics

• Adolescent
• Adult
• Cordyceps (chemistry)
• Female
• Granulomatosis with Polyangiitis (diagnosis, immunology)
• Humans
• Male
• Middle Aged
• Polysaccharides
• Predictive Value of Tests
• Serologic Tests (methods)