Abstract | BACKGROUND: METHODS: RESULTS: The assay showed adequate inter- and intra-batch imprecision and was suitable for routine use in the laboratory. Calprotectin concentration was significantly greater in patients with Crohn's disease compared with controls (n = 25, P <0.001) and patients with IBS (n = 25, P <0.001). CONCLUSION: A single calprotectin measurement may aid gastroenterologists in the differential diagnosis of Crohn's disease and IBS. Its use could decrease the number of invasive or radiological investigations undertaken in the latter group of patients.
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Authors | Julie Wassell, Sunil Dolwani, Magda Metzner, H Losty, Anthony Hawthorne |
Journal | Annals of clinical biochemistry
(Ann Clin Biochem)
Vol. 41
Issue Pt 3
Pg. 230-2
(May 2004)
ISSN: 0004-5632 [Print] England |
PMID | 15117438
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Leukocyte L1 Antigen Complex
|
Topics |
- Adult
- Aged
- Biomarkers
(analysis)
- Case-Control Studies
- Crohn Disease
(diagnosis)
- Enzyme-Linked Immunosorbent Assay
- Feces
(chemistry)
- Female
- Humans
- Inflammatory Bowel Diseases
(diagnosis, pathology)
- Intestinal Neoplasms
(diagnosis)
- Irritable Bowel Syndrome
(diagnosis)
- Leukocyte L1 Antigen Complex
(analysis)
- Male
- Middle Aged
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