Abstract | BACKGROUND: Plasma homocysteine (tHcy) is a risk factor for cardio- vascular diseases. Furthermore it has been associated with antioxidative status. Additionally balneotherapeutic sulphur baths have been shown to influence antioxidative status. METHODS: 40 patients with degenerative osteoarthrosis were randomised into two equal groups, a treatment group, receiving stationary spa therapy plus daily sulphur baths (sulphur group) and a control group receiving spa therapy alone (control group). Blood tHcy levels and urinary 8-OHdG (an indicator for oxidative stress) were measured at the beginning and the end of spa therapy. RESULTS: tHcy (micromol/l) was significantly reduced from 11.41 (+/-2.91) to 10.55 (+/-2.28) in the sulphur group (p=0.016) and rose insignificantly from 12.93 (+/-2.28) to 13.80 (+/-3.87) in the control group. 8-OHdG (ng 8-OHdG/mg creatinine) declined from 18.00 (+/-18.28) to 11.16 (+/-5.33) in the sulphur group (n.s.) and from 17.91 (+/-5.87) to 18.17 (+/-5.70) in the control group (n.s.). Differences between the two groups showed significant effects of sulphur baths for tHcy (p=0.006) but not for 8-OHdG (p=0.106). CONCLUSIONS: Sulphur baths exert beneficial effects on plasma tHcyt whereas effects on 8-OHdG seem to be unlikely.
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Authors | Valentin Leibetseder, Gerhard Strauss-Blasche, Franz Holzer, Wolfgang Marktl, Cem Ekmekcioglu |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 343
Issue 1-2
Pg. 105-11
(May 2004)
ISSN: 0009-8981 [Print] Netherlands |
PMID | 15115681
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antioxidants
- Homocysteine
- Sulfur
- 8-Hydroxy-2'-Deoxyguanosine
- Deoxyguanosine
- Creatine
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Topics |
- 8-Hydroxy-2'-Deoxyguanosine
- Antioxidants
- Baths
- Creatine
(urine)
- Deoxyguanosine
(analogs & derivatives, urine)
- Female
- Homocysteine
(blood)
- Humans
- Male
- Middle Aged
- Osteoarthritis
(blood, therapy, urine)
- Sulfur
(therapeutic use)
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