Conjunctival and tear film changes after vitamin C and E administration in non-insulin dependent diabetes mellitus.

The purpose of our research was to investigate the effect of supplementation with vitamin C and E on ocular surface cytology specimens and related parameters in diabetic patients.
60 patients were enrolled in the study. The patients were given vitamin C (1000 mg/day) and vitamin E (400 IU/day) for 10 days. Conjunctival brush cytology specimens were obtained before and after treatment. Schirmer tests, break-up time and ocular ferning tests were also performed.
Goblet cell densities were 50 cells/per field before and 59 cells/per field after supplementation (p=0.002). The stage of squamous metaplasia was 1.12+/-0.42 before and 0.88+/-0.41 after supplementation (p=0.011). The changes were accompanied with improved values for the Schirmer test (p<0.001), break up time (p=0.001), and ocular ferning (p<0.001).
Diabetes mellitus is associated with increased oxidative stress. Our study suggests that supplementation with antioxidant vitamins C and E probably plays an important role in improving the ocular surface milieu.
AuthorsVasileios Peponis, Stefanos Bonovas, Amalia Kapranou, Evangelia Peponi, Kalitsa Filioussi, Christina Magkou, Nikolaos M Sitaras
JournalMedical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 10 Issue 5 Pg. CR213-7 (May 2004) ISSN: 1234-1010 [Print] Poland
PMID15114272 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • Vitamin E
  • Ascorbic Acid
  • Antioxidants (metabolism)
  • Ascorbic Acid (therapeutic use)
  • Conjunctiva (drug effects)
  • Conjunctival Diseases (pathology)
  • Diabetes Mellitus, Type 2 (drug therapy)
  • Goblet Cells (metabolism)
  • Humans
  • Oxidative Stress
  • Tears (drug effects)
  • Time Factors
  • Vitamin E (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: