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Conjunctival and tear film changes after vitamin C and E administration in non-insulin dependent diabetes mellitus.

AbstractBACKGROUND:
The purpose of our research was to investigate the effect of supplementation with vitamin C and E on ocular surface cytology specimens and related parameters in diabetic patients.
MATERIAL/METHODS:
60 patients were enrolled in the study. The patients were given vitamin C (1000 mg/day) and vitamin E (400 IU/day) for 10 days. Conjunctival brush cytology specimens were obtained before and after treatment. Schirmer tests, break-up time and ocular ferning tests were also performed.
RESULTS:
Goblet cell densities were 50 cells/per field before and 59 cells/per field after supplementation (p=0.002). The stage of squamous metaplasia was 1.12+/-0.42 before and 0.88+/-0.41 after supplementation (p=0.011). The changes were accompanied with improved values for the Schirmer test (p<0.001), break up time (p=0.001), and ocular ferning (p<0.001).
CONCLUSIONS:
Diabetes mellitus is associated with increased oxidative stress. Our study suggests that supplementation with antioxidant vitamins C and E probably plays an important role in improving the ocular surface milieu.
AuthorsVasileios Peponis, Stefanos Bonovas, Amalia Kapranou, Evangelia Peponi, Kalitsa Filioussi, Christina Magkou, Nikolaos M Sitaras
JournalMedical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 10 Issue 5 Pg. CR213-7 (May 2004) ISSN: 1234-1010 [Print] Poland
PMID15114272 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • Vitamin E
  • Ascorbic Acid
Topics
  • Antioxidants (metabolism)
  • Ascorbic Acid (therapeutic use)
  • Conjunctiva (drug effects)
  • Conjunctival Diseases (pathology)
  • Diabetes Mellitus, Type 2 (drug therapy)
  • Goblet Cells (metabolism)
  • Humans
  • Oxidative Stress
  • Tears (drug effects)
  • Time Factors
  • Vitamin E (therapeutic use)

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