Abstract | BACKGROUND: The purpose of our research was to investigate the effect of supplementation with vitamin C and E on ocular surface cytology specimens and related parameters in diabetic patients. MATERIAL/METHODS: 60 patients were enrolled in the study. The patients were given vitamin C (1000 mg/day) and vitamin E (400 IU/day) for 10 days. Conjunctival brush cytology specimens were obtained before and after treatment. Schirmer tests, break-up time and ocular ferning tests were also performed. RESULTS: Goblet cell densities were 50 cells/per field before and 59 cells/per field after supplementation (p=0.002). The stage of squamous metaplasia was 1.12+/-0.42 before and 0.88+/-0.41 after supplementation (p=0.011). The changes were accompanied with improved values for the Schirmer test (p<0.001), break up time (p=0.001), and ocular ferning (p<0.001). CONCLUSIONS:
Diabetes mellitus is associated with increased oxidative stress. Our study suggests that supplementation with antioxidant vitamins C and E probably plays an important role in improving the ocular surface milieu.
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Authors | Vasileios Peponis, Stefanos Bonovas, Amalia Kapranou, Evangelia Peponi, Kalitsa Filioussi, Christina Magkou, Nikolaos M Sitaras |
Journal | Medical science monitor : international medical journal of experimental and clinical research
(Med Sci Monit)
Vol. 10
Issue 5
Pg. CR213-7
(May 2004)
ISSN: 1234-1010 [Print] United States |
PMID | 15114272
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Vitamin E
- Ascorbic Acid
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Topics |
- Antioxidants
(metabolism)
- Ascorbic Acid
(therapeutic use)
- Conjunctiva
(drug effects)
- Conjunctival Diseases
(pathology)
- Diabetes Mellitus, Type 2
(drug therapy)
- Goblet Cells
(metabolism)
- Humans
- Oxidative Stress
- Tears
(drug effects)
- Time Factors
- Vitamin E
(therapeutic use)
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