Abstract | AIM: MATERIAL AND METHODS: The study enrolled 20 COPD patients (mean age 64.9 +/- 1.9 years) with obstructive respiratory insufficiency of the second-third degree given nebuliser therapy with berotek as adjuvant to conventional treatment (the study group) and 12 COPD patients (mean age 69.7 +/- 2.5 years) given only conventional treatment (the control group). The following parameters were examined: ERF, BP, HD, AAB, OS (SaO2) in venous blood before and after treatment. Chronobiological studies of BP and HD were performed for 7 days at the beginning and end of the study. RESULTS:
Berotek efficacy manifested on the treatment day 3 as improvement in the symptoms, IRF, BP, a rise in SaO2 and PaCO2 and a fall in PaCO2 in venous blood. Circadian chronostructure of peakflowmetry, systolic and diastolic blood pressure, mean arterial pressure persisted. Circaseptal and circasemiseptal rhythms of BP and HD disappeared. CONCLUSION: Nebuliser therapy with berotek has a positive effect on clinical symptoms, ERF, BP, gas exchange in the lungs, SaO2, HD and their circadian chronostructure.
|
Authors | R M Zaslavskaia, G V Veklenko, K Zh Akhmetov, M M Teĭblium |
Journal | Terapevticheskii arkhiv
(Ter Arkh)
Vol. 76
Issue 2
Pg. 55-7
( 2004)
ISSN: 0040-3660 [Print] Russia (Federation) |
Vernacular Title | Vliianie nebulaĭzernoĭ terapii berotekom na funktsiiu vneshnego dykhaniia, bronkhial'nuiu prokhodimost', gemodinamiku, kislotno-shchelochnoe sostoianie, saturatsiiu kisloroda i ikh vremennuiu organizatsiiu u pozhilykh bol'nykh khronicheskoĭ obstruktivnoĭ bolezn'iu legkikh. |
PMID | 15106417
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Bronchodilator Agents
- Fenoterol
- Oxygen
|
Topics |
- Acid-Base Equilibrium
(drug effects)
- Administration, Inhalation
- Bronchi
(drug effects, physiopathology)
- Bronchodilator Agents
(administration & dosage, therapeutic use)
- Fenoterol
(administration & dosage, therapeutic use)
- Hemodynamics
(drug effects)
- Humans
- Middle Aged
- Nebulizers and Vaporizers
- Oxygen
(metabolism)
- Pulmonary Disease, Chronic Obstructive
(drug therapy, metabolism, physiopathology)
- Respiratory Mechanics
(drug effects)
- Treatment Outcome
|