Abstract | OBJECTIVE: The platelet membrane glycoprotein (GP) Ia/IIa plays a major part as a primary collagen receptor in platelet function. Previous studies indicated that variations of GPIa/IIa density and function are associated with the 807 C/T polymorphism of GPIa gene in American and Spanish Caucasian populations. This study investigated the correlation between acute coronary syndrome (ACS) and 807 C/T dimorphism of GPIa gene in Chinese of Han ethnicity. METHODS: RESULTS: The frequencies of both homozygotes and heterozygotes for T807 allele (TT+TC) were significantly higher in patients with AMI than in controls (62.16% vs 33.85%, P<0.01; odds ratio 3.21). The prevalence of (TT+TC) genotypes was also markedly higher in patients with UAP than in controls (65.79% vs 33.85%, P < 0.005; odds ratio 3.76). There was significant difference in the distribution of (TT+TC) genotypes not only between all patients and controls (64.00% vs 33.85%, P<0.005; odds ratio 3.47) but also between the two subgroups aged <60 years (70.00% vs 38.24%, P<0.005; odds ratio 3.77). However, there was no significant difference in the distribution of (TT+TC) genotypes between patients with AMI and with UAP. Platelet GPIa T807 allele remained significantly associated with AMI and UAP by multiple logistic regression (odds ratio 4.94). CONCLUSION: This study suggests a strong association between presence of GPIa T807 allele and ACS. T807 allele can be a marker of genetic susceptibility to ACS.
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Authors | Yonghui Zhao, Yanni Wang, Jiaqing Zhu |
Journal | Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
(Chin Med Sci J)
Vol. 19
Issue 1
Pg. 13-8
(Mar 2004)
ISSN: 1001-9294 [Print] China |
PMID | 15104219
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Alleles
- Angina, Unstable
(genetics)
- Asian People
- Case-Control Studies
- China
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Integrin alpha2
(genetics)
- Male
- Middle Aged
- Myocardial Infarction
(genetics)
- Odds Ratio
- Polymorphism, Genetic
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