Abstract | BACKGROUND: Recent evidence suggests that patients with allergic rhinitis have lower airway inflammation and a higher prevalence of bronchial hyperresponsiveness (BHR) regardless of asthma. OBJECTIVE: METHODS: Thirty-two nonasthmatic children with SAR in response to grass and/or weed pollens were recruited and separated into 2 groups. Group 1 was treated with triamcinolone acetonide (220 microg once daily) for 6 weeks, and group 2 received no intranasal corticosteroid treatment. Bronchial responsiveness to methacholine [concentration that caused a decrease in forced expiratory volume in 1 second of 20% (PC20)], eosinophil counts in sputum and peripheral blood, and eosinophil cationic protein (ECP) levels in sputum and serum were measured before and during grass pollen season. RESULTS: Twenty-eight patients completed the study. During the pollen season, methacholine PC20 significantly decreased in both groups when compared with the corresponding preseasonal values (P = .01 and P = .003, respectively). The mean percentage of sputum eosinophils increased significantly during the pollen season compared with preseasonal values in group 1 and group 2 (12.7% +/- 2.1% vs 16.5% +/- 2.1%, P = .007, and 11.0% +/- 2.0% vs 20.2% +/- 1.4%, P = .003, respectively). Median [interquartile ranges (IQR)] sputum ECP levels were significantly higher during the pollen season when compared with the preseasonal values in group 1 and group 2 [7.5 microg/L (3.5-36.0 microg/L) vs 35.5 microg/L (13.0-71.7 microg/L), P = .04, and 18.0 microg/L (6.0-36.0 microg/L) vs 69.0 microg/L (39.0-195.0 microg/L), P = .003, respectively], as were the serum ECP levels [6.0 microg/L (2.0-13.0 microg/L) vs 19.0 microg/L (14.0-43.5 microg/L), P = .004, and 6.0 microg/L (3.0-7.0 microg/L) vs 18.0 microg/L (6.0-36.0 microg/L), P = .001, respectively]. Although the mean number of eosinophils in blood increased during the pollen season in both groups, it was only significant in group 2 (70.0 +/- 20.0 vs 161.6 +/- 29.0, P = .02). CONCLUSIONS:
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Authors | Fazil Orhan, Bulent Enis Sekerel, Gonul Adalioglu, Munevver Pinar, Ayfer Tuncer |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 92
Issue 4
Pg. 438-45
(Apr 2004)
ISSN: 1081-1206 [Print] United States |
PMID | 15104196
(Publication Type: Comparative Study, Evaluation Study, Journal Article)
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Chemical References |
- Allergens
- Biomarkers
- Blood Proteins
- Eosinophil Granule Proteins
- Glucocorticoids
- Ribonucleases
- Triamcinolone Acetonide
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Topics |
- Adolescent
- Allergens
(adverse effects)
- Asthma
(complications, drug therapy, physiopathology)
- Biomarkers
(blood)
- Blood Proteins
(metabolism)
- Bronchial Hyperreactivity
(drug therapy, etiology, physiopathology)
- Bronchitis
(complications, drug therapy, physiopathology)
- Child
- Child Welfare
- Eosinophil Granule Proteins
- Eosinophils
(metabolism)
- Female
- Forced Expiratory Volume
(drug effects)
- Glucocorticoids
(therapeutic use)
- Humans
- Leukocyte Count
- Male
- Pollen
(adverse effects)
- Respiratory Function Tests
- Rhinitis, Allergic, Seasonal
(complications, drug therapy, physiopathology)
- Ribonucleases
(metabolism)
- Seasons
- Sputum
(chemistry, cytology, metabolism)
- Statistics as Topic
- Time Factors
- Treatment Outcome
- Triamcinolone Acetonide
(therapeutic use)
- Turkey
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