HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Psoriasis is not associated with IL-12p70/IL-12p40 production and IL12B promoter polymorphism.

Abstract
Psoriasis is a type-1 T cell-mediated, chronic inflammatory disease. Since interleukin (IL)-12p70 promotes the development of type-1 T cells, we investigated whether psoriasis is associated with an increased production of this cyctokine by blood cells. Results revealed that the production of IL-12p70 by cells of psoriasis patients stimulated by 1 and 10 ng per mL, but not 100 ng per mL of lipopolysaccharide (LPS) was higher (p=0.03) than that by cells of healthy volunteers. The production of IL-12p40 by patients cells upon stimulation with 0.1 ng per mL LPS, but not higher concentrations, was higher (p=0.02) than that by cells of healthy volunteers. No association between IL-12p70 production by blood cells and the severity of psoriasis was observed, nor was there a difference in the LPS-stimulated production of this cytokine between cells of the early and late onset type of patients. The frequencies of the various genotypes for the promoter region of the gene encoding IL-12p40 (IL12B) did not differ between psoriasis patients and controls. No association was observed between the various IL12B promoter genotypes and the LPS-stimulated production of IL-12p70 or IL-12p40 by blood cells. Together, psoriasis is not associated with a promoter polymorphism in the IL12B gene nor with the production of IL-12p70 by LPS-stimulated blood cells.
AuthorsNicolle H R Litjens, Mariena J A van der Plas, Bep Ravensbergen, Sandra C Numan-Ruberg, Yvette van Assen, H Bing Thio, Jaap T van Dissel, Esther van de Vosse, Peter H Nibbering
JournalThe Journal of investigative dermatology (J Invest Dermatol) Vol. 122 Issue 4 Pg. 923-6 (Apr 2004) ISSN: 0022-202X [Print] United States
PMID15102082 (Publication Type: Journal Article)
Chemical References
  • IL12B protein, human
  • Interleukin-12 Subunit p40
  • Lipopolysaccharides
  • Protein Subunits
  • Interleukin-12
Topics
  • Adolescent
  • Age of Onset
  • Blood Cells (drug effects, metabolism)
  • Female
  • Genotype
  • Humans
  • Interleukin-12 (blood, genetics)
  • Interleukin-12 Subunit p40
  • Lipopolysaccharides (pharmacology)
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Promoter Regions, Genetic (genetics)
  • Protein Subunits (blood)
  • Psoriasis (blood, epidemiology, genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: