Pharmacokinetics of the thymidine analog 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) in tumor-bearing rats.

Abstract	The thymidine analog 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) is incorporated into DNA and is resistant to catabolism. We performed pharmacokinetic measurements with [(14)C]FMAU and PET studies with [(11)C]FMAU using rats bearing several different syngeneic tumors. Among normal tissues, FMAU uptake reflected relative cell turnover rates. Among tumors, the highest uptake occurred in a rapidly growing colon carcinoma, but was similarly low in both rapidly and slowly growing prostate tumors. FMAU was not catabolized and was rapidly incorporated into DNA by small intestine and colon tumors. Results indicate that FMAU may be useful for imaging tissue DNA synthesis, although tumor uptake was modest and not well correlated with growth rate among the models examined.
Authors	James R Bading, Antranik H Shahinian, Amy Vail, Pravin Bathija, G W Koszalka, Robert T Koda, Mian M Alauddin, John D Fissekis, Peter S Conti
Journal	Nuclear medicine and biology (Nucl Med Biol) Vol. 31 Issue 4 Pg. 407-18 (May 2004) ISSN: 0969-8051 [Print] United States
PMID	15093810 (Publication Type: Comparative Study, Evaluation Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Carbon Radioisotopes DNA, Neoplasm Radiopharmaceuticals Arabinofuranosyluracil clevudine Thymidine
Topics	Adenocarcinoma (blood, diagnostic imaging, metabolism) Animals Arabinofuranosyluracil (analogs & derivatives, blood, pharmacokinetics) Carbon Radioisotopes (blood, pharmacokinetics) Cell Line, Tumor Colorectal Neoplasms (blood, diagnostic imaging, metabolism) DNA, Neoplasm (metabolism) Female Male Metabolic Clearance Rate Organ Specificity Prostatic Neoplasms (blood, diagnostic imaging, metabolism) Radionuclide Imaging Radiopharmaceuticals (blood, pharmacokinetics) Rats Rats, Inbred F344 Thymidine (analogs & derivatives, metabolism) Tissue Distribution

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