Abstract | OBJECTIVE: External cooling is commonly used to force induction of mild hypothermia but requires equipment, has a slow onset of action, and must be prolonged to provide permanent neurologic benefits after hypoxic- ischemia. It is unknown whether the method for inducing mild hypothermia affects neurologic outcome after near-drowning. The objective of the study was to induce mild hypothermia with neurotensin analog NT77 or external cooling in a rat model of near-drowning. We hypothesize that NT77 would be more effective for improving neurologic outcome than external cooling of the same duration. DESIGN: SETTING: Laboratory investigation. SUBJECTS: Forty-eight rats. INTERVENTIONS: MEASUREMENTS: MAIN RESULTS:
Neurologic deficit score at 72 hrs after asphyxial cardiac arrest was lower with neurotensin- induced hypothermia (score, 0) and prolonged external cooling (score, 0) vs. normothermic control (score, 20) and brief external cooling (score, 18; p <.05). Latency time in the Morris water maze 15 days after asphyxial cardiac arrest was decreased with neurotensin- induced hypothermia (14+/-11 secs) and prolonged external cooling (18+/-9 secs) vs. normothermic control (74+/-17 secs) and brief external cooling (78+/-18 secs, p <.05). There was less ischemic neuronal damage with neurotensin- induced hypothermia (28+/-24%) and prolonged external cooling (21+/-14%) vs. normothermic control (61+/-32%) and brief external cooling (51+/-32%). CONCLUSIONS:
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Authors | Laurence M Katz, Amanda Young, Jonathan E Frank, Yuanfan Wang, Kyunam Park |
Journal | Critical care medicine
(Crit Care Med)
Vol. 32
Issue 3
Pg. 806-10
(Mar 2004)
ISSN: 0090-3493 [Print] United States |
PMID | 15090966
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
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Topics |
- Animals
- Asphyxia
(therapy)
- Disease Models, Animal
- Heart Arrest
(therapy)
- Hypothermia, Induced
(methods)
- Hypoxia, Brain
(prevention & control)
- Near Drowning
(therapy)
- Neurotensin
(analogs & derivatives, therapeutic use)
- Random Allocation
- Rats
- Statistics, Nonparametric
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