Abstract | BACKGROUND: METHODS: Cross-over, non-blinded, volunteer study using five healthy males. Eight milligrams of oral and sublingual cyproheptadine were administered on separate occasions with a one-week washout period. Sublingual arm subjects were pretreated with 50 g of oral activated charcoal 30 min prior to cyproheptadine, to prevent any gut absorption. Serum cyproheptadine concentration was measured at baseline, 30 min, and 1, 2, 3, 4, 6, 8, and 10 h by liquid chromatography and mass spectroscopy. RESULTS: Mean C(max) for oral and sublingual were 30.0 microg/L and 4.0 microg/L respectively: mean T(max) were 4 h and 9.6 h; mean AUC were 209 and 25 microg x hr/L. Mean +/- SEM within-subject difference between oral and sublingual C(max) was 25.9 +/- 4.1 (p = 0.003) and AUC was 184 +/- 31 (p = 0.004). CONCLUSIONS:
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Authors | Narendra Gunja, Michael Collins, Andis Graudins |
Journal | Journal of toxicology. Clinical toxicology
(J Toxicol Clin Toxicol)
Vol. 42
Issue 1
Pg. 79-83
( 2004)
ISSN: 0731-3810 [Print] United States |
PMID | 15083941
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Serotonin Antagonists
- Cyproheptadine
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Topics |
- Administration, Oral
- Administration, Sublingual
- Adolescent
- Adult
- Area Under Curve
- Chromatography, Liquid
- Cross-Over Studies
- Cyproheptadine
(administration & dosage, pharmacokinetics)
- Humans
- Male
- Mass Spectrometry
- Middle Aged
- Serotonin Antagonists
(administration & dosage, pharmacokinetics)
- Serotonin Syndrome
(drug therapy, metabolism)
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