Abstract | OBJECTIVE: METHODS: Thirty-nine patients with a first AMI within 6 hours of onset were randomly assigned to the treatment group (1,600,000 IU IV monteplase, n = 19) or the nontreatment group (n = 20), followed by PCI. Clinical outcomes were then evaluated. RESULTS: Patient characteristics did not differ between the 2 groups. A significantly higher number of patients in the monteplase group achieved Thrombolysis In Myocardial Infarction trial (TIMI) grade 2 flow or more at the first angiography (84.2% vs 40.0%; P <.005), reduced number of devices (1.44 vs 1.80 devices, P <.05), and reduced procedure times (59.7 vs 86.7 minutes; P <.01), with no differences in peak creatine kinase and rates of major complications and no reflow or distal embolization. Observation over an average of 5.5 months revealed a tendency toward lower target lesion revascularization rates in the monteplase group (17.6% vs 31.6%) but no intergroup difference in rates of major complications. Pretreatment quantitative coronary angioplasty only showed a significant difference in minimal lumen diameter and percent diameter stenosis in the acute phase (1.13 mm in the monteplase group vs 0.66 mm in the nontreatment group, 57.0% vs 73.0%; P <.05). (99m)Tc-QGS (quantitative electrocardiographically gated single-photon emission computed tomographic scintigraphy) showed no intergroup differences in left ventricular end-diastolic volume index, end- systolic volume index, and ejection fraction in the acute and chronic phases. CONCLUSIONS: Our results suggest that PCI with antecedent mutant t-PA for AMI not only accelerates reperfusion, thereby facilitating PCI, but also attenuates restenosis in the chronic phase.
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Authors | Hideaki Kurihara, Satoru Matsumoto, Ritsu Tamura, Kenji Yachiku, Atsuyuki Nakata, Tsutomu Nakagawa, Takashi Yoshino, Tatsuo Matsuyama |
Journal | American heart journal
(Am Heart J)
Vol. 147
Issue 4
Pg. E14
(Apr 2004)
ISSN: 1097-6744 [Electronic] United States |
PMID | 15077097
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Platelet Aggregation Inhibitors
- Vasodilator Agents
- monteplase
- Nicorandil
- Plasminogen Activators
- Aspirin
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Topics |
- Aged
- Angioplasty, Balloon, Coronary
- Aspirin
(therapeutic use)
- Combined Modality Therapy
- Coronary Angiography
- Coronary Restenosis
(epidemiology)
- Female
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(drug therapy, therapy)
- Nicorandil
(therapeutic use)
- Plasminogen Activators
(therapeutic use)
- Platelet Aggregation Inhibitors
(therapeutic use)
- Stents
- Vasodilator Agents
(therapeutic use)
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